发明公开
- 专利标题： Human artificial chromosome containting human antibody lambda light chain and non-human animal containting the human artificial chromosome capable of genetic transmission
- 专利标题（中）： 人类人工染色体与人抗体的λ轻链，和非人类动物与遗传的人类人工染色体转移
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申请号： EP08010546.3申请日： 2002-05-10
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公开(公告)号： EP1970448A1公开(公告)日： 2008-09-17
- 发明人: Kuroiwa, Yoshimi , Tomizuka, Kazuma , Yoshida, Hitoshi , Ishida, Isao
- 申请人： Kirin Pharma Kabushiki Kaisha
- 申请人地址： 26-1, Jingumae 6-chome Shibuya-ku Tokyo 150-8011 JP
- 专利权人： Kirin Pharma Kabushiki Kaisha
- 当前专利权人： Kirin Pharma Kabushiki Kaisha
- 当前专利权人地址： 26-1, Jingumae 6-chome Shibuya-ku Tokyo 150-8011 JP
- 代理机构： HOFFMANN EITLE
- 优先权： JP2001142371 20010511
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A01K67/027 ; C07K16/00 ; C12P21/08
摘要：
The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody λ light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the non-human animal or an offspring thereof; and a human antibody-producing mouse carrying the human artificial chromosome.
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