发明公开
EP1992639A4 PEPTIDE VACCINE FOR INDUCING PRODUCTION OF ANTI-AMYLOID- -PEPTIDE ANTIBODY
审中-公开
肽疫苗诱导产生抗淀粉样蛋白抗体的
- 专利标题: PEPTIDE VACCINE FOR INDUCING PRODUCTION OF ANTI-AMYLOID- -PEPTIDE ANTIBODY
- 专利标题(中): 肽疫苗诱导产生抗淀粉样蛋白抗体的
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申请号: EP07714358申请日: 2007-02-16
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公开(公告)号: EP1992639A4公开(公告)日: 2009-08-26
- 发明人: YANO AKIRA , NISHIZAWA TOSHIKI , MIWA YOSHIKATSU
- 申请人: HAYASHIBARA BIOCHEM LAB
- 专利权人: HAYASHIBARA BIOCHEM LAB
- 当前专利权人: HAYASHIBARA BIOCHEM LAB
- 优先权: JP2006044808 2006-02-22
- 主分类号: C07K14/47
- IPC分类号: C07K14/47 ; A61K38/00 ; A61K39/00 ; A61P25/28 ; C07K7/06 ; C07K7/08
摘要:
The object is to provide a peptide vaccine for prevention and/or treatment of a disease induced by amyloid-β-peptide such as Alzheimer‘s disease. Disclosed is a peptide having: a peptide segment which has an amino acid sequence for a multiagretope-type T-cell epitope having an established immunological memory or an amino acid sequence for a peptide containing the epitope; and a peptide segment which has an amino acid sequence for a B-cell epitope located at a specific cite of amyloid-β-peptide or an amino acid sequence for a peptide containing the epitope, the two peptide segments being linked via a linker, wherein the peptide also has therein an amino acid sequence for a cell-binding motif of a cell adhesion molecule.
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