发明公开
EP1992639A4 PEPTIDE VACCINE FOR INDUCING PRODUCTION OF ANTI-AMYLOID- -PEPTIDE ANTIBODY 审中-公开
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PEPTIDE VACCINE FOR INDUCING PRODUCTION OF ANTI-AMYLOID- -PEPTIDE ANTIBODY
摘要:
The object is to provide a peptide vaccine for prevention and/or treatment of a disease induced by amyloid-β-peptide such as Alzheimer‘s disease. Disclosed is a peptide having: a peptide segment which has an amino acid sequence for a multiagretope-type T-cell epitope having an established immunological memory or an amino acid sequence for a peptide containing the epitope; and a peptide segment which has an amino acid sequence for a B-cell epitope located at a specific cite of amyloid-β-peptide or an amino acid sequence for a peptide containing the epitope, the two peptide segments being linked via a linker, wherein the peptide also has therein an amino acid sequence for a cell-binding motif of a cell adhesion molecule.
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