发明公开
- 专利标题： METHOD FOR NITRATING ISOUREA
- 专利标题（中）： 方法氮化异脲的
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申请号： EP07738656.3申请日： 2007-03-15
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公开(公告)号： EP1997802A1公开(公告)日： 2008-12-03
- 发明人: YAMAGATA, Kazuyuki , SEKO, Shinzo
- 申请人： Sumitomo Chemical Company, Limited
- 申请人地址： 27-1, Shinkawa 2-chome, Chuo-ku Tokyo 104-8260 JP
- 专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人： Sumitomo Chemical Company, Limited
- 当前专利权人地址： 27-1, Shinkawa 2-chome, Chuo-ku Tokyo 104-8260 JP
- 代理机构： Vossius & Partner
- 优先权： JP2006072577 20060316
- 国际公布： WO2007105793 20070920
- 主分类号： C07C275/70
- IPC分类号： C07C275/70 ; C07C273/18 ; C07B61/00
摘要：
An object of the present invention is to industrially advantageously produce N-nitroisoureas or a salt thereof which is useful as a synthetic intermediate for pharmaceuticals and pesticides. The present invention relates to a process for producing a compound represented by the formula (2):
wherein R 1 , R 2 and R 3 are as defined below, or a salt thereof, which comprises reacting a compound represented by the formula (1):
wherein R 1 represents an optionally substituted straight-chain or branched C 1 to C 6 alkyl group, R 2 and R 3 are the same or different and represent an optionally substituted straight-chain or branched C 1 to C 6 alkyl group, a cycloalkyl group or a substituted aryl group, or R 2 and R 3 simultaneously represent a hydrogen atom, or a salt thereof with a nitrating agent in the presence of sulfur trioxide.
wherein R 1 , R 2 and R 3 are as defined below, or a salt thereof, which comprises reacting a compound represented by the formula (1):
wherein R 1 represents an optionally substituted straight-chain or branched C 1 to C 6 alkyl group, R 2 and R 3 are the same or different and represent an optionally substituted straight-chain or branched C 1 to C 6 alkyl group, a cycloalkyl group or a substituted aryl group, or R 2 and R 3 simultaneously represent a hydrogen atom, or a salt thereof with a nitrating agent in the presence of sulfur trioxide.
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