公开(公告)号：EP2511270A1

公开(公告)日：2012-10-17

申请号：EP10833431.9

申请日：2010-11-29

申请人： Sumitomo Chemical Company, Limited

发明人： YAMAGATA, Kazuyuki

IPC分类号： C07D277/20 ,  C07D277/32

CPC分类号： C07D277/32

摘要： A method for producing 5-(aminomethyl)-2-chlorothiazole, which comprises the step of mixing a compound represented by formula (2):

a mineral acid and a nitrite salt together.

摘要翻译： 一种生产5-（氨基甲基）-2-氯噻唑的方法，其包括将式（2）表示的化合物：无机酸和亚硝酸盐一起混合的步骤。

公开(公告)号：EP1997802A1

公开(公告)日：2008-12-03

申请号：EP07738656.3

申请日：2007-03-15

申请人： Sumitomo Chemical Company, Limited

发明人： YAMAGATA, Kazuyuki ,  SEKO, Shinzo

IPC分类号： C07C275/70 ,  C07C273/18 ,  C07B61/00

CPC分类号： C07C273/1854 ,  C07C2601/14 ,  C07C275/70

摘要： An object of the present invention is to industrially advantageously produce N-nitroisoureas or a salt thereof which is useful as a synthetic intermediate for pharmaceuticals and pesticides. The present invention relates to a process for producing a compound represented by the formula (2):

wherein R 1 , R 2 and R 3 are as defined below, or a salt thereof, which comprises reacting a compound represented by the formula (1):

wherein R 1 represents an optionally substituted straight-chain or branched C 1 to C 6 alkyl group, R 2 and R 3 are the same or different and represent an optionally substituted straight-chain or branched C 1 to C 6 alkyl group, a cycloalkyl group or a substituted aryl group, or R 2 and R 3 simultaneously represent a hydrogen atom, or a salt thereof with a nitrating agent in the presence of sulfur trioxide.