发明授权
- 专利标题: PREPARATION OF ESLICARBAZEPINE AND RELATED COMPOUNDS BY ASYMMETRIC HYDROGENATION
- 专利标题(中): 制造业和相关化合物艾司不对称氢化
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申请号: EP07747757.8申请日: 2007-04-11
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公开(公告)号: EP2004610B1公开(公告)日: 2010-08-25
- 发明人: YU, Bing , LI, Wenge , LEARMONTH, David
- 申请人: BIAL - Portela & Ca., S.A.
- 申请人地址: À Av. da Siderurgia Nacional 4745-457 S. Mamede do Coronado PT
- 专利权人: BIAL - Portela & Ca., S.A.
- 当前专利权人: BIAL - Portela & Ca., S.A.
- 当前专利权人地址: À Av. da Siderurgia Nacional 4745-457 S. Mamede do Coronado PT
- 代理机构: Cottrill, Emily Elizabeth Helen
- 优先权: GB0607317 20060411
- 国际公布: WO2007117166 20071018
- 主分类号: C07D223/22
- IPC分类号: C07D223/22
摘要:
A process for preparing a compound of the formula IA or IB, wherein R is a!kyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalkyl represents a saturated alicyclic gτoup with 3 to 6 carbon atoms; the term aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II, wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.
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