公开(公告)号：EP2297042A2

公开(公告)日：2011-03-23

申请号：EP09721339.1

申请日：2009-03-17

申请人： Bial-Portela & CA, S.A.

发明人： LEARMONTH, David Alexander ,  BELIAEV, Alexander ,  LI, Wenge

IPC分类号： C01G55/00 ,  C07D233/84 ,  C07D311/74 ,  C07D335/06 ,  C07D407/04 ,  C07D409/04

CPC分类号： C07D311/04 ,  C07D405/04 ,  C07F15/0053 ,  C07F15/008

摘要： A process for preparing the S or R enantiomer of a compound of formula A, (see formula (B) and formula (A)), the process comprising subjecting a compound of formula B to asymmetric hydrogenation in the presence of a chiral transition metal catalyst and a source of hydrogen.

公开(公告)号：EP2297042B1

公开(公告)日：2013-07-10

申请号：EP09721339.1

申请日：2009-03-17

申请人： Bial-Portela & CA, S.A.

发明人： LEARMONTH, David Alexander ,  BELIAEV, Alexander ,  LI, Wenge

IPC分类号： C01G55/00 ,  C07D233/84 ,  C07D311/74 ,  C07D335/06 ,  C07D407/04 ,  C07D409/04

CPC分类号： C07D311/04 ,  C07D405/04 ,  C07F15/0053 ,  C07F15/008

公开(公告)号：EP2004610B1

公开(公告)日：2010-08-25

申请号：EP07747757.8

申请日：2007-04-11

申请人： BIAL - Portela & Ca., S.A.

发明人： YU, Bing ,  LI, Wenge ,  LEARMONTH, David

IPC分类号： C07D223/22

CPC分类号： C07D223/22

摘要： A process for preparing a compound of the formula IA or IB, wherein R is a!kyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalkyl represents a saturated alicyclic gτoup with 3 to 6 carbon atoms; the term aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II, wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.

公开(公告)号：EP2004610A1

公开(公告)日：2008-12-24

申请号：EP07747757.8

申请日：2007-04-11

申请人： BIAL - Portela & Ca., S.A.

发明人： YU, Bing ,  LI, Wenge ,  LEARMONTH, David

IPC分类号： C07D223/22

CPC分类号： C07D223/22

摘要： A process for preparing a compound of the formula IA or IB, wherein R is a!kyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalkyl represents a saturated alicyclic gτoup with 3 to 6 carbon atoms; the term aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II, wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.