发明公开
EP2022788A1 NOVEL CRYSTAL OF 3-Ý5-Ý4-(CYCLOPENTYLOXY)-2- HYDROXYBENZOYL¨-2-Ý(3-HYDROXY-1,2-BENZISOXAZOL-6- YL)METHOXY¨PHENYL¨PROPIONIC ACID
有权
NEUER KRISTALL VON 3- [5- [4-（环己基）-2-羟基苯甲酰基] -2 - [（3-羟基-1,2-苯并咪唑-6-基）甲氧基]苯基]丙酸
- 专利标题： NOVEL CRYSTAL OF 3-Ý5-Ý4-(CYCLOPENTYLOXY)-2- HYDROXYBENZOYL¨-2-Ý(3-HYDROXY-1,2-BENZISOXAZOL-6- YL)METHOXY¨PHENYL¨PROPIONIC ACID
- 专利标题（中）： NEUER KRISTALL VON 3- [5- [4-（环己基）-2-羟基苯甲酰基] -2 - [（3-羟基-1,2-苯并咪唑-6-基）甲氧基]苯基]丙酸
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申请号： EP07744104.6申请日： 2007-05-25
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公开(公告)号： EP2022788A1公开(公告)日： 2009-02-11
- 发明人: YONEZAWA, Kenji , KOTSUBO, Hironori , BABA, Yasutaka , TADA, Yukie
- 申请人： TOYAMA CHEMICAL CO., LTD.
- 申请人地址： 2-5, 3-chome, Nishishinjuku, Shinjuku-ku Tokyo 160-0023 JP
- 专利权人： TOYAMA CHEMICAL CO., LTD.
- 当前专利权人： TOYAMA CHEMICAL CO., LTD.
- 当前专利权人地址： 2-5, 3-chome, Nishishinjuku, Shinjuku-ku Tokyo 160-0023 JP
- 代理机构： Hartz, Nikolai
- 优先权： JP2006146220 20060526
- 国际公布： WO2007138996 20071206
- 主分类号： C07D261/12
- IPC分类号： C07D261/12
摘要：
The crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.0, 16.0, 23.3, 23.7 and 26.3°and the crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.6, 23.1, 24.7, 25.6 and 26.0° on 2θ of diffraction angle in a powder X-ray diffraction pattern have a small specific volume, are hard to be charged with electricity, are easily handled and are useful for an active pharmaceutical ingredient of excellent anti-rheumatic agents.
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