发明公开
EP2029161A2 USE OF NON-CATALYTIC FORM OF HEPARANASE AND PEPTIDES THEREOF FOR REVERSING THE ANTI-COAGULANT EFFECTS OF HEPARINOIDS
审中-公开
乙酰肝素酶和多肽非催化FORM OF及其用于逆转抗凝血类肝素的地方使用
- 专利标题： USE OF NON-CATALYTIC FORM OF HEPARANASE AND PEPTIDES THEREOF FOR REVERSING THE ANTI-COAGULANT EFFECTS OF HEPARINOIDS
- 专利标题（中）： 乙酰肝素酶和多肽非催化FORM OF及其用于逆转抗凝血类肝素的地方使用
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申请号： EP07736304.2申请日： 2007-05-10
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公开(公告)号： EP2029161A2公开(公告)日： 2009-03-04
- 发明人: VLODAVSKY, Israel , ILAN, Neta , LEVY-ADAM, Flonia , KATZ, Ben-Zion
- 申请人： Hadasit Medical Research Services & Development Ltd. , The Medical Research Fund at the Tel-Aviv Sourasky Medical Center
- 申请人地址： P.O. Box 12000 91120 Jerusalem IL
- 专利权人： Hadasit Medical Research Services & Development Ltd.,The Medical Research Fund at the Tel-Aviv Sourasky Medical Center
- 当前专利权人： Hadasit Medical Research Services & Development Ltd.,The Medical Research Fund at the Tel-Aviv Sourasky Medical Center
- 当前专利权人地址： P.O. Box 12000 91120 Jerusalem IL
- 代理机构： Delorme, Nicolas
- 优先权： IL17557106 20060511
- 国际公布： WO2007132445 20071122
- 主分类号： A61K38/47
- IPC分类号： A61K38/47 ; A61P7/00
摘要：
The present invention relates to inhibition of heparinoids anti-coagulation activity by a non-active form of a eukaryotic endoglycosidase or any fragment or peptide thereof comprising at least one heparin-binding domain. More particularly, the invention provides compositions and methods for the inhibition of heparinoids anti-coagulation activity and for the treatment of coagulation related pathologic clinical conditions, using a non-active form of mammalian heparanase or peptides thereof comprising at least one heparin-binding domain.
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