专利检索 ap:("Hadasit Medical Research Services & Development Ltd." OR "The Medical Research Fund at the Tel-Aviv Sourasky Medical Center") AND inv:"LEVY-ADAM, Flonia" 第 1 页

1.

发明公开
USE OF NON-CATALYTIC FORM OF HEPARANASE AND PEPTIDES THEREOF FOR REVERSING THE ANTI-COAGULANT EFFECTS OF HEPARINOIDS 审中-公开
标题翻译：乙酰肝素酶和多肽非催化FORM OF及其用于逆转抗凝血类肝素的地方使用

公开(公告)号：EP2029161A2

公开(公告)日：2009-03-04

申请号：EP07736304.2

申请日：2007-05-10

申请人： Hadasit Medical Research Services & Development Ltd. , The Medical Research Fund at the Tel-Aviv Sourasky Medical Center

发明人： VLODAVSKY, Israel , ILAN, Neta , LEVY-ADAM, Flonia , KATZ, Ben-Zion

IPC分类号： A61K38/47 , A61P7/00

CPC分类号： A61K38/47

摘要： The present invention relates to inhibition of heparinoids anti-coagulation activity by a non-active form of a eukaryotic endoglycosidase or any fragment or peptide thereof comprising at least one heparin-binding domain. More particularly, the invention provides compositions and methods for the inhibition of heparinoids anti-coagulation activity and for the treatment of coagulation related pathologic clinical conditions, using a non-active form of mammalian heparanase or peptides thereof comprising at least one heparin-binding domain.