发明公开
- 专利标题: MUTANT MICROORGANISM HAVING IMPROVED PRODUCTION ABILITY OF BRANCHED AMINO ACID AND METHOD FOR PREPARING BRANCHED AMINO ACID USING THE SAME
- 专利标题(中): 支链氨基酸提高生产能力的突变微生物及用其制备支链氨基酸的方法
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申请号: EP07715659.4申请日: 2007-03-14
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公开(公告)号: EP2038403A1公开(公告)日: 2009-03-25
- 发明人: LEE, Sang Yup , PARK, Jin Hwan , LEE, Kwang Ho , KIM, Tae Yong
- 申请人: Korea Advanced Institute of Science and Technology
- 申请人地址: 373-1, Guseong-Dong, Yuseong-Ku Daejeon 305-701 KR
- 专利权人: Korea Advanced Institute of Science and Technology
- 当前专利权人: Korea Advanced Institute of Science and Technology
- 当前专利权人地址: 373-1, Guseong-Dong, Yuseong-Ku Daejeon 305-701 KR
- 代理机构: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权: KR20070005268 20070117
- 国际公布: WO2008088104 20080724
- 主分类号: C12N1/16
- IPC分类号: C12N1/16
摘要:
The present invention relates to mutant microorganisms having improved productivity of branched-chain amino acids, and a method for producing branched-chain amino acids using the mutant microorganisms. More specifically, relates to mutant microorganisms having improved productivity of L-valine, which are produced by attenuating or deleting a gene encoding an enzyme involved in L-isoleucine biosynthesis, a gene encoding an enzyme involved in L-leucine, and a gene encoding an enzyme involved in D-pantothenic acid biosynthesis, and mutating a gene encoding an enzyme involved in L-valine biosynthesis, such that the expression thereof is increased, as well as a method for producing L-valine using the mutant microorganisms. The inventive mutant microorganisms produced by site- specific mutagenesis and metabolic pathway engineering can produce branched-chain amino acids, particularly L-valine, with high efficiency, and thus will be useful as industrial microorganisms for producing L-valine.
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