发明公开
- 专利标题： POST-TRANSLATIONALLY MODIFIED NEUROTROPHINS
- 专利标题（中）： 后期改变神经痛
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申请号： EP07786268.8申请日： 2007-07-23
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公开(公告)号： EP2046823A1公开(公告)日： 2009-04-15
- 发明人: BARBEITO, Luis , PEHAR, Mariana , CASSINA, Patricia , ALZARI, Pedro M.
- 申请人： Institut Pasteur , Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.) , Facultad de Medicina, Universidad de la Republica , Centre National de la Recherche Scientifique
- 申请人地址： 25-28 Rue du Docteur Roux 75724 Paris Cédex 15 FR
- 专利权人： Institut Pasteur,Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.),Facultad de Medicina, Universidad de la Republica,Centre National de la Recherche Scientifique
- 当前专利权人： Institut Pasteur,Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.),Facultad de Medicina, Universidad de la Republica,Centre National de la Recherche Scientifique
- 当前专利权人地址： 25-28 Rue du Docteur Roux 75724 Paris Cédex 15 FR
- 代理机构： Paris, Fabienne
- 优先权： EP06291195 20060724
- 国际公布： WO2008012049 20080131
- 主分类号： C07K14/48
- IPC分类号： C07K14/48 ; C07K14/475 ; C07K1/107 ; G01N33/53 ; C07K16/22 ; A61P25/00 ; A61K38/18 ; A61K39/395
摘要：
The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.
公开/授权文献
- EP2046823B1 POST-TRANSLATIONALLY MODIFIED NEUROTROPHINS 公开/授权日：2012-11-21
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