公开(公告)号：EP2046823B1

公开(公告)日：2012-11-21

申请号：EP07786268.8

申请日：2007-07-23

申请人： Institut Pasteur ,  Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.) ,  Facultad de Medicina, Universidad de la Republica ,  Centre National de la Recherche Scientifique

发明人： BARBEITO, Luis ,  PEHAR, Mariana ,  CASSINA, Patricia ,  ALZARI, Pedro M.

IPC分类号： C07K14/48 ,  C07K14/475 ,  C07K1/107 ,  G01N33/53 ,  C07K16/22 ,  A61P25/00 ,  A61K38/18 ,  A61K39/395

CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K39/3955 ,  C07K14/475 ,  C07K14/48

摘要： The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.

公开(公告)号：EP1648503A2

公开(公告)日：2006-04-26

申请号：EP04764149.3

申请日：2004-07-23

申请人： INSTITUT PASTEUR ,  Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.)

发明人： BARBEITO, Luis Hector ,  ESTEVEZ, Alvaro, G., Dept. of Phys. & Biophysics ,  BECKMAN, Joseph, S. ,  PEHAR, Mariana, Inst. Inv. Biologicas Clemente E. ,  ALZARI, Pedro ,  CASSINA, Maria Patricia Departamento de Histologia

IPC分类号： A61K39/385 ,  A61P25/28 ,  A61K39/395 ,  A61K39/39 ,  C12N15/12 ,  C12N15/63 ,  C07K16/22 ,  C07K14/475 ,  A01K67/027

CPC分类号： C07K14/475 ,  A61K38/185 ,  A61K39/0005 ,  A61K39/0007 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/22

摘要： The present invention relates to novel methods for combatting cell degeneration or dysfunction resulting from neuroinflammatory conditions. The invention especially relates to the use, in the preparation of a medicament for the treatment of neurodegenerative disease associated with neuroinflammation, of an immunogenic compound which is capable of inducing an immune response against a proapoptotic neurotrophin, or an effective amount of a hapten combined with appropriate carriers and/or adjuvants to render the resulting combination capable of inducing an immune response against a proapoptotic neurotrophin. Also disclosed are compositions for the active or passive immunization against neuronal or glial cell apoptosis caused by neuroinflammantion as well as methods and means useful for said active or passive immunization.

公开(公告)号：EP1882697B1

公开(公告)日：2010-04-21

申请号：EP06291195.3

申请日：2006-07-24

申请人： INSTITUT PASTEUR ,  Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.) ,  Facultad de Medicina, Universidad de la Republica

发明人： Barbeito, Luis ,  Pehar, Mariana ,  Cassina, Patricia ,  Alzari, Pedro M.

IPC分类号： C07K16/22 ,  A61K39/395 ,  A61P25/00 ,  G01N33/53 ,  C07K14/48 ,  C07K14/475 ,  C07K1/107 ,  A61K38/18

CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K39/3955 ,  C07K14/475 ,  C07K14/48

摘要： The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.

公开(公告)号：EP2046823A1

公开(公告)日：2009-04-15

申请号：EP07786268.8

申请日：2007-07-23

申请人： Institut Pasteur ,  Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.) ,  Facultad de Medicina, Universidad de la Republica ,  Centre National de la Recherche Scientifique

发明人： BARBEITO, Luis ,  PEHAR, Mariana ,  CASSINA, Patricia ,  ALZARI, Pedro M.

IPC分类号： C07K14/48 ,  C07K14/475 ,  C07K1/107 ,  G01N33/53 ,  C07K16/22 ,  A61P25/00 ,  A61K38/18 ,  A61K39/395

CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K39/3955 ,  C07K14/475 ,  C07K14/48

摘要： The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.

公开(公告)号：EP1882697A1

公开(公告)日：2008-01-30

申请号：EP06291195.3

申请日：2006-07-24

申请人： INSTITUT PASTEUR ,  Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.) ,  Facultad de Medicina, Universidad de la Republica

发明人： Barbeito, Luis ,  Pehar, Mariana ,  Cassina, Patricia ,  Alzari, Pedro M.

IPC分类号： C07K14/48 ,  C07K14/475 ,  C07K1/107 ,  G01N33/53 ,  C07K16/22 ,  A61P25/00 ,  A61K38/18 ,  A61K39/395

CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K39/3955 ,  C07K14/475 ,  C07K14/48

摘要： The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.

摘要翻译： 本发明描述了神经营养因子经历翻译后修饰，并且这些翻译后修饰介导神经营养蛋白的促凋亡和/或前神经突活性。 这些翻译后修饰特别包括硝化和构象不同二聚体的形成，以及异构低聚物如四聚体和八聚体。 本发明还涉及与这种修饰的神经营养因子竞争的化合物，以及与所述修饰的神经营养蛋白结合的化合物。 因此，本发明提供了用于治疗涉及慢性疼痛和/或神经元损失的病症或疾病的有用试剂。

公开(公告)号：EP1500399A1

公开(公告)日：2005-01-26

申请号：EP03291837.7

申请日：2003-07-24

申请人： INSTITUT PASTEUR ,  Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.)

发明人： Barbeito, Luis Hector ,  Estevez, Alvaro G., Dpt. of Physiologoy and Bioph. ,  Beckman, Joseph S. ,  Pehar, Mariana ,  Alzari, Pedro ,  Cassina, Maria Patricia, Depart. de Histologia

IPC分类号： A61K39/00 ,  C07K16/22 ,  A61K39/385 ,  A61K48/00 ,  A61P25/28 ,  A61K39/395

CPC分类号： C07K14/475 ,  A61K38/185 ,  A61K39/0005 ,  A61K39/0007 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/22

摘要： The present invention relates to novel methods for combatting cell degeneration or dysfunction resulting from neuroinflammatory conditions. The invention especially relates to the use, in the preparation of a medicament for the treatment of neurodegenerative disease associated with neuroinflammation, of an immunogenic compound which is capable of inducing an immune response against a proapoptotic neurotrophin, or an effective amount of a hapten combined with appropriate carriers and/or adjuvants to render the resulting combination capable of inducing an immune response against a proapoptotic neurotrophin. Also disclosed are compositions for the active or passive immunization against neuronal or glial cell apoptosis caused by neuroinflammantion as well as methods and means useful for said active or passive immunization.

摘要翻译： 本发明涉及一种用于打击细胞变性或功能障碍从神经炎条件导致的新方法。 本发明的爱尤其涉及使用，在制备用于治疗与神经炎症的免疫原性化合物的所有的相关联的，神经变性疾病的治疗，其能够抵抗促凋亡的神经营养因子的免疫应答的诱导的，或在有效量的半抗原与组合的 适当的载体和/或佐剂以使能够诱导对抗促凋亡的神经营养因子的免疫反应的所得组合。 所以圆盘游离缺失是针对神经元或通过neuroinflammantion以及方法引起神经胶质细胞凋亡的主动或被动免疫的组合物和用于将所述主动或被动免疫是有用的。