发明公开
EP2054381A2 PHARMACODYNAMIC HYBRIDS ENDOWED OF HYPOGLYCEMIC AND NO-DONOR ACTIVITIES OBTAINED COMBINING HYDROXYLATED DERIVATIVES OF GLIBENCLAMIDE AND NITROOXY-SUBSTITUTED CARBOXYLIC ACIDS
审中-公开
格列本脲和NITROOXYSUBSTITUIERTEN碳氢酸的羟基化衍生物合成所获得药效HYBRID有降血糖和无捐助者的影响
- 专利标题： PHARMACODYNAMIC HYBRIDS ENDOWED OF HYPOGLYCEMIC AND NO-DONOR ACTIVITIES OBTAINED COMBINING HYDROXYLATED DERIVATIVES OF GLIBENCLAMIDE AND NITROOXY-SUBSTITUTED CARBOXYLIC ACIDS
- 专利标题（中）： 格列本脲和NITROOXYSUBSTITUIERTEN碳氢酸的羟基化衍生物合成所获得药效HYBRID有降血糖和无捐助者的影响
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申请号： EP07804717.2申请日： 2007-08-06
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公开(公告)号： EP2054381A2公开(公告)日： 2009-05-06
- 发明人: BALSAMO, Aldo , CALDERONE, Vincenzo , RAPPOSELLI, Simona , MARCHETTI, Piero , TORRI, Scilla
- 申请人： UNIVERSITA' DI PISA
- 申请人地址： Lungarno Pacinotti, 43/44 56126 Pisa IT
- 专利权人： UNIVERSITA' DI PISA
- 当前专利权人： UNIVERSITA' DI PISA
- 当前专利权人地址： Lungarno Pacinotti, 43/44 56126 Pisa IT
- 代理机构： Celestino, Marco
- 优先权： ITPI20060103 20060807
- 国际公布： WO2008017925 20080214
- 主分类号： C07C311/59
- IPC分类号： C07C311/59 ; A61K31/64 ; A61P3/10
摘要：
Compound featuring a hypoglycemic action and in the meantime a release of nitric oxide (NO), said compound having the following general formula (I) : where at least one among R, R1, and R2 is a substitute comprising an nitroxy-ester group bound to a acyl aliphatic, aromatic or aliphatic-aromatic group. The compound can be in particular, used to treat patients affected by NO endogenous deficit responsive to diabetes mellitus of type 2.
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