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    PROCESS FOR DETERMINING S-NITROSOTHIOLS IN BIOLOGICAL FLUIDS
    4.
    发明公开
    PROCESS FOR DETERMINING S-NITROSOTHIOLS IN BIOLOGICAL FLUIDS 有权
    用于确定S-亚硝基硫醇生物体液

    公开(公告)号：EP2054727A2

    公开(公告)日：2009-05-06

    申请号：EP07789530.8

    申请日：2007-07-23

    申请人： UNIVERSITA' DI PISA

    发明人： POMPELLA, Alfonso ,  PAOLICCHI, Aldo ,  BRAMANTI, Emilia ,  BARSACCHI, Renata ,  FRANZINI, Maria ,  VECOLI, Cecilia

    IPC分类号： G01N33/68

    CPC分类号： C12Q1/37 ,  C12Q1/48 ,  G01N33/6815 ,  G01N33/6842 ,  G01N33/94 ,  G01N2333/9108 ,  G01N2333/96425 ,  G01N2400/00

    摘要： A process for determining S-nitrosothiols, in particular S-nitrosoglutathione, in biological fluids that is easy, selective, cheap with respect to the prior art, which requires the use of equipment commonly available in laboratories, at low cost, which can be used by not qualified operators. The process is based on the hydrolysis of S-nitrosoglutathione (GSNO) by an enzyme, in particular γ-glutamyltranspeptidase (GGT). This enzyme hydrolizes the residual γ-glutamyl of GSNO for giving glutamate (GIu) and S-nitroso-cysteinylglycine (GIyCySNO). In the presence of ions of transition metals GGT speeds up the release of NO since the intermediate that is formed, the GIyCySNO, is is much more sensitive to a metal- dependent decomposition. Advantageously, the amount of nitric oxide present in the sample is measured through a reaction thereof with 4,5 diaminof luorescein (DAF-2), said reaction creating a fluorescent compound in an amount proportional to the S-nitrosothiol amount present in the sample. Alternatively, the amount of released NO can be measured by a chemiluminescence analyser, commercially available. In the presence of biological fluids having complex matrix, the introduction of the enzyme is done after separation of the S-nitrosothiol from the other components of the fluid.

    A PROCESS OF CONTROLLED RADICAL GRAFTING OF A POLYOLEFIN
    6.
    发明授权
    A PROCESS OF CONTROLLED RADICAL GRAFTING OF A POLYOLEFIN 有权
    METHOD FOR A聚烯烃的可控自由基接枝

    公开(公告)号：EP1641838B1

    公开(公告)日：2008-06-11

    申请号：EP04737157.0

    申请日：2004-06-24

    申请人： UNIVERSITA' DI PISA

    发明人： CIARDELLI, Francesco ,  PASSAGLIA, Elisa ,  COIAI, Serena

    IPC分类号： C08F8/00 ,  C08F8/34 ,  C08F8/30 ,  C08F255/02

    CPC分类号： C08F255/02

    摘要： The present invention relates to a controlled radical grafting process of a polyolefin derived from monomeric units including a olefins. This process comprises the reaction of the polyolefin and at least one radical reaction initiator with a grafting system which comprises at least one grafting compound having an electron donator heterocyclic aromatic ring conjugated to at least one -HC=CRIR2 group in which at least one of R1 and R2 is an electron acceptor functional be performed continuously in an extruder or discontinuously in a mechanical mixer.

    DRILLING MASK FOR IMPLANTING A TRANSPEDICULAR SCREW
    7.
    发明公开
    DRILLING MASK FOR IMPLANTING A TRANSPEDICULAR SCREW 有权
    钻模用于植入的TRANSPEDIKELSCHRAUBE的

    公开(公告)号：EP2693958A2

    公开(公告)日：2014-02-12

    申请号：EP12748528.2

    申请日：2012-04-10

    申请人： Universita Di Pisa

    发明人： CONDINO, Sara ,  FERRARI, Vincenzo ,  PARCHI, Paolo ,  LISANTI, Michele

    IPC分类号： A61B17/17

    CPC分类号： A61B17/1757

    摘要： A drilling mask (100) for implanting a transpedicular screw (50) on a spine section (200) comprises a guide body (10) with a distal surface (12) and a proximal surface (14), opposite to the distal surface (12) and facing towards the spine section (200). The guide body (10) comprises a reference element (21) obtained on the proximal surface (14) and arranged to contact the spinous process (220), a guide channel (25) that extends starting from the distal surface (12), which is arranged to work as drilling guide for drilling the pedicle (250) and implanting the transpedicular screw (50), and a plurality, of support elements (22, 23) made on the proximal surface (14), associated with the reference element (21), arranged to contact side parts of the spine section (220). The guide body (10) comprises at least one reference portion (10a), which represents the central portion of the mask, equipped with the reference element (21), and configured to be put at the spinous process (220) and at least one lateral guide portion (10b, 10c), cooperating with the reference portion (10a), which comprises the guide channel (25) for drilling the pedicle (250) and the support elements (22, 23) laterally with respect to the spinous process (220).