发明公开
- 专利标题： Enteric-coated glucosinolates and beta-thioglucosidases
- 专利标题（中）： 葡萄糖硫酸葡萄糖苷和β-硫代葡萄糖苷类
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申请号： EP08104379.6申请日： 2008-06-11
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公开(公告)号： EP2065034A2公开(公告)日： 2009-06-03
- 发明人: West, Leslie George , Windsor, Nicole Lee , Gaonkar, Anilkumar Ganapati , Matusheski, Nathan V. , Kim, Nam-Cheol , Ludwig, Cathy Jean , Lawrence, Leslie Lewis
- 申请人： Kraft Foods Holdings, Inc.
- 申请人地址： Three Lakes Drive Northfield, IL 60093 US
- 专利权人： Kraft Foods Holdings, Inc.
- 当前专利权人： Kraft Foods Holdings, Inc.
- 当前专利权人地址： Three Lakes Drive Northfield, IL 60093 US
- 代理机构： Smaggasgale, Gillian Helen
- 优先权： US761843 20070612
- 主分类号： A61K9/16
- IPC分类号： A61K9/16 ; A61K9/50
摘要：
The present invention relates to a particulate composition comprising enteric-coated glucosinolate and beta-thioglucosidase particles. The present invention further provides a method of converting glucosinolate to isothiocyanate in the small intestine comprising orally administering to a subject an enteric-coated chemoprotectant precursor composition comprising enteric-coated glucosinolate and beta-thioglucosidase particles. In another aspect, uncoated glucosinolate and beta-thioglucosidase particles may be provided in an enteric-coated capsule. Preferably, the glucosinolate is glucoraphanin and the beta-thioglucosidase is myrosinase. The enteric coating targets the compound for release in the small intestine where beta-thiaglucosidase enzyme converts glucosinolate to chemoprotectant isothiocyanate.
公开/授权文献
- EP2065034A3 Enteric-coated glucosinolates and beta-thioglucosidases 公开/授权日：2011-08-31
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