发明公开
- 专利标题： Polycycloalkylpurines as adenosine receptor antagonists
- 专利标题（中）： 聚环烷基嘌呤als腺苷激动剂
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申请号： EP09151275.6申请日： 2000-11-13
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公开(公告)号： EP2070930A1公开(公告)日： 2009-06-17
- 发明人: Kiesman, William F. , Dowling, James E. , Ensinger, Carol L. , Kumaravel, Gnanasambandam , Petter, Russel C. , Lin, Ko Chung , Chang, He Xi
- 申请人： Biogen Idec MA, Inc.
- 申请人地址： 14 Cambridge Center Cambridge Massachusetts 02142 US
- 专利权人： Biogen Idec MA, Inc.
- 当前专利权人： Biogen Idec MA, Inc.
- 当前专利权人地址： 14 Cambridge Center Cambridge Massachusetts 02142 US
- 代理机构： UEXKÜLL & STOLBERG
- 优先权： US165191P 19991112
- 主分类号： C07D473/22
- IPC分类号： C07D473/22 ; C07D473/06 ; C07D519/00 ; A61K31/52 ; A61P9/00 ; A61P25/28 ; C07F9/6561 ; C07D311/00 ; C07D493/08 ; C07D307/00
摘要：
The invention is based on the discovery that compounds of Formula (I) are unexpectedly highly potent and selective inhibitors of the adenosine A 1 receptor. Adenosine A 1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula (I).
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