发明公开
- 专利标题: TRANSDERMALES THERAPEUTISCHES SYSTEM MIT ZWEIPHASIGEM FREISETZUNGSPROFIL
- 专利标题(英): Transdermal therapeutic system with two-phase releasing profile
- 专利标题(中): 透皮治疗系统两相释放曲线
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申请号: EP07802907.1申请日: 2007-08-27
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公开(公告)号: EP2079458A2公开(公告)日: 2009-07-22
- 发明人: TACK, Johannes , SCHURAD, Björn , MÜLLER-SCHUBERT, Antje , HOROWSKI, Reinhard
- 申请人: Axxonis Pharma AG
- 申请人地址: Schöneberger Strasse 15 10963 Berlin DE
- 专利权人: Axxonis Pharma AG
- 当前专利权人: Axxonis Pharma AG
- 当前专利权人地址: Schöneberger Strasse 15 10963 Berlin DE
- 代理机构: Wablat, Wolfgang
- 优先权: DE102006048130 20061006
- 国际公布: WO2008043601 20080417
- 主分类号: A61K9/70
- IPC分类号: A61K9/70 ; A61K47/06 ; A61K47/10 ; A61K47/32 ; A61K47/44 ; C07D457/00 ; A61K47/16
摘要:
The present invention relates to a transdermal therapeutic system (TTS) comprising an impermeable covering layer, a matrix containing an ergolin compound of formula (I) or the physiologically compatible salt or derivative thereof, wherein R1 represents an H atom or a halogen atom and R2 an alkyl group with 1 to 4 carbon atoms and ------ a single or double bond, and a removable protective layer, the ergolin compound or the physiologically compatible salt or derivative thereof being stabilized by an antioxidant and a basic polymer. The TTS is characterized in that the matrix contains at least one hydrocarbon having 8 to 18 carbon atoms in a linear or branched chain and carrying a functional group at the end of the alkyl chain, and/or aloe vera oil so that, in a first phase (0-5 hours after application), only 0 to 20 % of the therapeutically desired steady state plasma concentration of the ergolin compound is achieved and, in a second phase (5-20 hours after application), the therapeutically desired steady state plasma concentration of the ergolin compound is achieved.
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