发明公开
EP2079464A2 INTRAVENOUS AND ORAL DOSING OF A DIRECT-ACTING AND REVERSIBLE P2Y12 INHIBITOR
审中-公开
一个直接作用的和可逆的P2Y12抑制剂的静脉内和口服剂量
- 专利标题: INTRAVENOUS AND ORAL DOSING OF A DIRECT-ACTING AND REVERSIBLE P2Y12 INHIBITOR
- 专利标题(中): 一个直接作用的和可逆的P2Y12抑制剂的静脉内和口服剂量
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申请号: EP08747561.2申请日: 2008-05-02
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公开(公告)号: EP2079464A2公开(公告)日: 2009-07-22
- 发明人: GRETLER, Daniel, D. , CONLEY, Pamela, B. , ANDRE, Patrick , HUTCHALEELAHA, Athiwat , PHILLIPS, David, R. , PANDEY, Anjali , WOLIN, Huang , SCARBOROUGH, Robert, M.
- 申请人: Portola Pharmaceuticals, Inc.
- 申请人地址: 270 East Grand Avenue Suite 22 South San Francisco California 94080 US
- 专利权人: Portola Pharmaceuticals, Inc.
- 当前专利权人: Portola Pharmaceuticals, Inc.
- 当前专利权人地址: 270 East Grand Avenue Suite 22 South San Francisco California 94080 US
- 代理机构: Campbell, Patrick John Henry
- 优先权: US915649P 20070502; US947921P 20070703
- 国际公布: WO2008137753 20081113
- 主分类号: A61K31/216
- IPC分类号: A61K31/216 ; A61K31/517 ; A61P7/02
摘要:
The invention provides methods and compositions for rapid and reversible inhibition of platelet aggregation in human subjects in need thereof by administering compounds of the formula: (I) alone or in combination with a second agent which can be aspirin or a thrombolytic agent.
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