发明公开
- 专利标题： HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS
- 专利标题（中）： 杂环化合物抗发炎剂
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申请号： EP07819423.0申请日： 2007-10-29
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公开(公告)号： EP2089393A1公开(公告)日： 2009-08-19
- 发明人: FERRAND, Sandrine , GLICKMAN, Fraser , LEBLANC, Catherine , RITCHIE, Cathy , SHAW, Duncan , STIEFL, Nikolaus Johannes , FURET, Pascal , IMBACH, Patricia , STAUFFER, Frédéric , CAPRARO, Hans-Georg , GESSIER, François , GAUL, Christoph , ALBAUGH, Pamela A. , CHOPIUK, Greg
- 申请人： NOVARTIS AG
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： NOVARTIS AG
- 当前专利权人： NOVARTIS AG
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： Vögeli-Lange, Regina
- 优先权： EP06123156 20061030
- 国际公布： WO2008052734 20080508
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/5025 ; A61P9/00 ; A61P19/00 ; A61P25/00
摘要：
A compound of Formula Ia or Ib in free or salt or solvate form, where R1, R2, R3, R4, R5 R20, R24, R25, X, Y and Z have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. These compounds are also useful for treating diseases mediated by the Pi3k receptor, the JAK-2 receptor and the TRK receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
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