发明公开
EP2094685A2 3-HETEROARYL (AMINO OR AMIDO)-1- (BIPHENYL OR PHENYLTHIAZOLYL) CARBONYLPIPERDINE DERIVATIVES AS OREXIN RECEPTOR INHIBITORS
有权
3 - 杂芳基(氨基或酰氨基)-1-(联苯OR phenylthiazolyl)CARBONYLPIPERDINDERIVATE作为抑制剂阿立新
- 专利标题: 3-HETEROARYL (AMINO OR AMIDO)-1- (BIPHENYL OR PHENYLTHIAZOLYL) CARBONYLPIPERDINE DERIVATIVES AS OREXIN RECEPTOR INHIBITORS
- 专利标题(中): 3 - 杂芳基(氨基或酰氨基)-1-(联苯OR phenylthiazolyl)CARBONYLPIPERDINDERIVATE作为抑制剂阿立新
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申请号: EP07849292.3申请日: 2007-11-29
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公开(公告)号: EP2094685A2公开(公告)日: 2009-09-02
- 发明人: AISSAOUI, Hamed , BOSS, Christoph , GUDE, Markus , KOBERSTEIN, Ralf , SIFFERLEN, Thierry
- 申请人: Actelion Pharmaceuticals Ltd.
- 申请人地址: Gewerbestrasse 16 4123 Allschwil CH
- 专利权人: Actelion Pharmaceuticals Ltd.
- 当前专利权人: Actelion Pharmaceuticals Ltd.
- 当前专利权人地址: Gewerbestrasse 16 4123 Allschwil CH
- 代理机构: Ruhlmann, Eric
- 优先权: PCT/IB2006/054549 20061201
- 国际公布: WO2008065626 20080605
- 主分类号: C07D401/12
- IPC分类号: C07D401/12 ; C07D417/14 ; C07D513/04 ; A61K31/4188 ; A61K31/4523 ; A61K31/506 ; A61P25/00
摘要:
The invention relates to piperidine compounds of formula (I) wherein X-R1 represents -N(H)-pyrimidinyl, wherein said pyrimidinyl is unsubstituted or mono-substituted wherein the substituent is selected from (C1-4)alkyl or halogen, or X-R1 represents -NH-C(O)-heterocyclyl, wherein the heterocyclyl is selected from benzofuranyl and imidazo[2,1-b]-thiazolyl, wherein said heterocyclyl is unsubstituted or independently mono-, di-, or tri-substituted wherein the substituents are independently selected from (C1-4)alkyl; A represents a phenyl- or thiazolyl-group, wherein the phenyl or thiazolyl is unsubstituted or mono-substituted with (C1-4)alkyl; B represents a phenyl-group, wherein the phenyl is unsubstituted or mono-, or di- substituted, wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, trifluoromethyl, cyano and halogen; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.
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