发明公开
EP2113504A1 Preparation of N-6 demethylated, 9,10-dihydrolysergic acid alkyl esters
审中-公开
Zubereitung von N-6-demethylierten 9,10-DihydrolysergsäureAlkylestern
- 专利标题： Preparation of N-6 demethylated, 9,10-dihydrolysergic acid alkyl esters
- 专利标题（中）： Zubereitung von N-6-demethylierten 9,10-DihydrolysergsäureAlkylestern
-
申请号： EP08155371.1申请日： 2008-04-29
-
公开(公告)号： EP2113504A1公开(公告)日： 2009-11-04
- 发明人: The designation of the inventor has not yet been filed
- 申请人： LEK Pharmaceuticals d.d.
- 申请人地址： Verovskova 57 1526 Ljubljana SI
- 专利权人： LEK Pharmaceuticals d.d.
- 当前专利权人： LEK Pharmaceuticals d.d.
- 当前专利权人地址： Verovskova 57 1526 Ljubljana SI
- 代理机构： Demsar, Marija
- 主分类号： C07D457/02
- IPC分类号： C07D457/02 ; C07D457/04 ; C07D457/06 ; A61K31/48 ; A61P25/00
摘要：
A process for producing N -6 demethylated 9,10-dihydrolysergic acid alkyl ester is described, which comprises a step of N -6 demethylation of 9,10-dihydrolysergic acid alkyl esters with chloroformate and wherein the N -6 demethylation step is performed in the presence of an organic catalyst. Further, a process for converting a compound of formula I (DHLSAIkyI) into a compound of formula II (DHLSAIkyI-F) comprises the steps of: providing (and maintaining) a reaction medium free of water and/or HCI, and reacting DHLSAIkyI with chloroformate in said reaction medium free of water and/or HCI, to obtain the compound of formula II (DHLSAIkyI-F).
信息查询
