-
公开(公告)号：EP3901266A1
公开(公告)日：2021-10-27
申请号：EP20170926.8
申请日：2020-04-22
发明人： Vogelsang, Matja , Tuta, Nika , Gaser, Dominik
摘要： The present invention belongs to the field of biotechnology, and specifically relates to recombinant gene expression.
The invention concerns a method of recombinant gene expression from a Chinese Hamster Ovary (CHO) cell, by using super-enhancer sequences for increased gene expression. Thus, the invention provides a method for producing an engineered CHO cell by introducing into the cell an exogenous nucleic acid molecule into or within 500 kb upstream or downstream of a super-enhancer as expression-enhancing sequence. The invention further provides an engineered CHO cell produced by the method. The invention further provides a method of producing a recombinant polypeptide. The invention is further directed to the use of a super-enhancer for transgene expression.-
公开(公告)号：EP3891151A1
公开(公告)日：2021-10-13
申请号：EP19829406.8
申请日：2019-12-05
发明人： LENGAUER, Hannes
IPC分类号： C07D487/04 , A61K31/4985 , A61P29/00
-
公开(公告)号：EP2755957B2
公开(公告)日：2019-05-15
申请号：EP12759136.0
申请日：2012-09-14
发明人： MARAS, Nened , ZUPANCIC, Borut
IPC分类号： C07D239/47 , C07D239/69 , C07D405/12 , C07D487/04 , A61K31/519
-
公开(公告)号：EP2697251B1
公开(公告)日：2019-02-27
申请号：EP12713737.0
申请日：2012-04-12
IPC分类号： C07K14/435 , C12N5/00 , C07K14/43
-
公开(公告)号：EP3339329A1
公开(公告)日：2018-06-27
申请号：EP16206398.6
申请日：2016-12-22
CPC分类号： C08B37/0009 , C08B31/006 , C08K3/11 , C08K2003/0856
摘要： The present invention relates to an efficient route of synthesis of iron (III) carboxymaltose complexes, in particular ferric carboxymaltose.
-
公开(公告)号：EP2771326B1
公开(公告)日：2017-12-20
申请号：EP12783926.4
申请日：2012-10-26
发明人： ZUPANCIC, Borut , MARAS, Nenad , STERK, Damjan
IPC分类号： C07D239/56 , C07D405/12 , C07D487/04 , A61K31/519 , C07D239/46
CPC分类号： C07D239/46 , C07D239/56 , C07D405/12 , C07D487/04
-
-
8.发明授权PHARMACEUTICAL COMPOSITION COMPRISING (E)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULFONYL)AMINO]PYRIMIDIN-5-YL-(3R,5S)-3,5-DIHYDROXYHEPT-6-ENOIC ACID 有权包含（E）-7- [4-（4-氟苯基）-6-异丙基-2- [甲基（甲基磺酰基）氨基]嘧啶-5-基 - （3R，5S）-3,5-二羟基庚基-6 - 烯酸
公开(公告)号：EP1968593B1
公开(公告)日：2017-08-23
申请号：EP06829701.9
申请日：2006-12-18
IPC分类号： A61K31/505 , A61K9/20 , A61P9/10 , A61P3/06 , A61K45/06
CPC分类号： A61K31/505 , A61K9/2018 , A61K9/2866 , A61K45/06
-
公开(公告)号：EP2850087B1
公开(公告)日：2017-08-02
申请号：EP13714298.0
申请日：2013-04-05
发明人： STAVBER, Gaj , CASAR, Zdenko
IPC分类号： C07F5/04
CPC分类号： C07F5/04
-
-
-
-
-
-
-
-
搜索结果
470 条记录 (耗时 0.03 秒)
