发明公开
EP2118099A2 PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS 有权
方法2-噻唑作为激酶抑制剂的合成

  • 专利标题: PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS
  • 专利标题(中): 方法2-噻唑作为激酶抑制剂的合成
  • 申请号: EP08708929.8
    申请日: 2008-02-13
  • 公开(公告)号: EP2118099A2
    公开(公告)日: 2009-11-18
  • 发明人: MOUSSY, AlainREGINAULT, PhilippeBELLAMY, FrançoisLERMET, Anne
  • 申请人: AB Science
  • 申请人地址: 3, avenue George V 75008 Paris FR
  • 专利权人: AB Science
  • 当前专利权人: AB Science
  • 当前专利权人地址: 3, avenue George V 75008 Paris FR
  • 代理机构: Portal, Frédéric
  • 优先权: US889587P 20070213
  • 国际公布: WO2008098949 20080821
  • 主分类号: C07D417/04
  • IPC分类号: C07D417/04
PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS
摘要:
The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula (I) which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.
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