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1.发明授权OXAZOLE AND THIAZOLE DERIVATIVES AS SELECTIVE PROTEIN KINASE INHIBITORS (C-KIT) 有权恶唑和噻唑衍生物，以作为选择性蛋白激酶抑制剂（C-KIT）
公开(公告)号：EP2736904B1
公开(公告)日：2016-03-16
申请号：EP12741307.8
申请日：2012-07-24
申请人： AB Science
发明人： BENJAHAD, Abdellah , MOUSSY, Alain , CHEVENIER, Emmanuel , PICOUL, Willy , LERMET, Anne , PEZ, Didier , MARTIN, Jason , SANDRINELLI, Franck
IPC分类号： C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , A61P35/00 , A61K31/422 , A61K31/427
CPC分类号： A61K31/422 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14
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2.发明公开OXAZOLE AND THIAZOLE DERIVATIVES AS SELECTIVE PROTEIN KINASE INHIBITORS (C-KIT) 有权恶唑和噻唑衍生物，以作为选择性蛋白激酶抑制剂（C-KIT）
公开(公告)号：EP2736904A1
公开(公告)日：2014-06-04
申请号：EP12741307.8
申请日：2012-07-24
申请人： AB Science
发明人： BENJAHAD, Abdellah , MOUSSY, Alain , CHEVENIER, Emmanuel , PICOUL, Willy , LERMET, Anne , PEZ, Didier , MARTIN, Jason , SANDRINELLI, Franck
IPC分类号： C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , A61P35/00 , A61K31/422 , A61K31/427
CPC分类号： A61K31/422 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof: wherein R
1 , R
2 , R
3 , A, Q, W and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.-
3.发明公开
公开(公告)号：EP2118099A2
公开(公告)日：2009-11-18
申请号：EP08708929.8
申请日：2008-02-13
申请人： AB Science
IPC分类号： C07D417/04
CPC分类号： C07D417/04
摘要： The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula (I) which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.
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4.发明授权
公开(公告)号：EP2118099B1
公开(公告)日：2011-07-06
申请号：EP08708929.8
申请日：2008-02-13
申请人： AB Science
IPC分类号： C07D417/04
CPC分类号： C07D417/04
摘要： The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula (I) which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.
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