发明公开
EP2125811A2 DERIVES DE N-(AMINO-HETEROARYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDES, LEUR PRÉPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权
N-(氨基 - 杂芳基)-1H-吡咯并吡啶-2-甲酰胺衍生物,它们的制备和治疗用途

  • 专利标题: DERIVES DE N-(AMINO-HETEROARYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDES, LEUR PRÉPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
  • 专利标题(英): N-(amino-heteroaryl)-1h-pyrrolopyridine-2-carboxamides derivatives, preparation thereof and their use in therapy
  • 专利标题(中): N-(氨基 - 杂芳基)-1H-吡咯并吡啶-2-甲酰胺衍生物,它们的制备和治疗用途
  • 申请号: EP07872409.3
    申请日: 2007-12-20
  • 公开(公告)号: EP2125811A2
    公开(公告)日: 2009-12-02
  • 发明人: DUBOIS, LaurentEVANNO, YannickGILLE, CatherineMACHNIK, DavidMALANDA, André
  • 申请人: Sanofi-Aventis
  • 申请人地址: 174 Avenue de France 75013 Paris FR
  • 专利权人: Sanofi-Aventis
  • 当前专利权人: Sanofi-Aventis
  • 当前专利权人地址: 174 Avenue de France 75013 Paris FR
  • 代理机构: Kugel, Dominique
  • 优先权: FR0611353 20061226
  • 国际公布: WO2008093024 20080807
  • 主分类号: C07D471/04
  • IPC分类号: C07D471/04
DERIVES DE N-(AMINO-HETEROARYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDES, LEUR PRÉPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
摘要:
The invention relates to compounds of the general formula (I) in which: the pyrrolopyridine node is optionally substituted at the 4, 5, 6 and / or 7 carbonated position by one or more identical or different X substituents selected from a hydrogen or halogen atom or a C1C6-alkyl, C3-C7- cycloalkyl, C3-C7cycloalkyl-C1C6-alkylene, C1C6-fluoroalkyl, C1C6-alkoxyl, C3-C7- cycloalkoxyl, C3-C7-cycloalkyl-C1C6-alkylene-O-, C1C6-fluoroalkoxyl, cyano, C1-C6- thioalkyl, -S(O)-C1C6-alkyl, -S(O)-C2-C6-alkyl, SF5, C(O)NR1R2, SO2NR1R2, nitro, NR1R2, OCONR1R2, NR3COR4, NR3CONR1R2, NR3SO2R5, NR3SO2NR1R2, aryl-C1C6- alkylene, heteroaryl-C1C6-alkylene, aryl or heteroaryl group, the aryl and heteroaryl being optionally substituted; Z1, Z2, Z3, Z4 independently represent a nitrogen atom or a C(R6) group, one of which at least corresponds to a nitrogen atom and one of which at least corresponds to a C(R6) group; Z in a cyclic amine bound by the nitrogen atom or cyclic amine bound by the nitrogen and of the formula NraRb; wherein the compounds can be in the base state or in the state of an addition salt for an acid, or in a hydrate or solvate state. The invention also relates to a method for making the same and to the use thereof in therapy.
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