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19 条记录 (耗时 0.03 秒)

    DÉRIVÉS DE CARBOXAMIDES AZABICYCLIQUES, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE
    1.
    发明公开
    DÉRIVÉS DE CARBOXAMIDES AZABICYCLIQUES, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE 有权
    氮杂双环甲酰胺衍生物及其制备及其治疗用途

    公开(公告)号：EP2235016A1

    公开(公告)日：2010-10-06

    申请号：EP09720539.7

    申请日：2009-01-20

    申请人： Sanofi-Aventis

    发明人： DUBOIS. Laurent ,  EVANNO, Yannick ,  LECLERC, Odile ,  MALANDA, André

    IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P29/00 ,  A61P11/00 ,  A61P3/00

    CPC分类号： C07D471/04

    摘要： The invention relates to the compounds of general formula (I) in which X
    1, X
    2, X
    3 and X
    4 are, independently of one another, a nitrogen atom or a C‑R
    1 group; W is an oxygen or sulphur atom; n is equal to 0, 1, 2 or 3; Y is an optionally substituted aryl or heteroaryl; A is a bicyclic heteroaryl of formula (II) where Z
    1 , Z
    2 , Z
    3 and Z
    4 are, independently of one another, a carbon atom, a nitrogen atom or a C‑R
    2a group; Z
    5, Z
    6 and Z
    7 are, independently of one another, a nitrogen atom or a C‑R
    b group; Z
    8 is a carbon atom; in the form of a base or of an addition salt with an acid, and also in the form of a hydrate or of a solvate. Process for preparation thereof and therapeutic use.

    DERIVES DE N-(AMINO-HETEROARYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDES, LEUR PRÉPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
    3.
    发明公开
    DERIVES DE N-(AMINO-HETEROARYL)-1H-PYRROLOPYRIDINE-2-CARBOXAMIDES, LEUR PRÉPARATION ET LEUR APPLICATION EN THERAPEUTIQUE 有权
    N-（氨基 - 杂芳基）-1H-吡咯并吡啶-2-甲酰胺衍生物，它们的制备和治疗用途

    公开(公告)号：EP2125811A2

    公开(公告)日：2009-12-02

    申请号：EP07872409.3

    申请日：2007-12-20

    申请人： Sanofi-Aventis

    发明人： DUBOIS, Laurent ,  EVANNO, Yannick ,  GILLE, Catherine ,  MACHNIK, David ,  MALANDA, André

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04 ,  C07D213/74 ,  C07D241/20

    摘要： The invention relates to compounds of the general formula (I) in which: the pyrrolopyridine node is optionally substituted at the 4, 5, 6 and / or 7 carbonated position by one or more identical or different X substituents selected from a hydrogen or halogen atom or a C1C6-alkyl, C3-C7- cycloalkyl, C3-C7cycloalkyl-C1C6-alkylene, C1C6-fluoroalkyl, C1C6-alkoxyl, C3-C7- cycloalkoxyl, C3-C7-cycloalkyl-C1C6-alkylene-O-, C1C6-fluoroalkoxyl, cyano, C1-C6- thioalkyl, -S(O)-C1C6-alkyl, -S(O)-C2-C6-alkyl, SF5, C(O)NR1R2, SO2NR1R2, nitro, NR1R2, OCONR1R2, NR3COR4, NR3CONR1R2, NR3SO2R5, NR3SO2NR1R2, aryl-C1C6- alkylene, heteroaryl-C1C6-alkylene, aryl or heteroaryl group, the aryl and heteroaryl being optionally substituted; Z1, Z2, Z3, Z4 independently represent a nitrogen atom or a C(R6) group, one of which at least corresponds to a nitrogen atom and one of which at least corresponds to a C(R6) group; Z in a cyclic amine bound by the nitrogen atom or cyclic amine bound by the nitrogen and of the formula NraRb; wherein the compounds can be in the base state or in the state of an addition salt for an acid, or in a hydrate or solvate state. The invention also relates to a method for making the same and to the use thereof in therapy.

    DERIVES DE N- (AMINO-HETEROARYL) - 1H-INDOLE-2 -CARBOXAMIDES COMME ANTAGONISTES DES RECEPTEURS DE TYPE TRPV1 OU VR1
    4.
    发明公开
    DERIVES DE N- (AMINO-HETEROARYL) - 1H-INDOLE-2 -CARBOXAMIDES COMME ANTAGONISTES DES RECEPTEURS DE TYPE TRPV1 OU VR1 有权
    N-（氨基杂芳基）-1H-吲哚-2-甲酰胺衍生物及其制备和治疗用途

    公开(公告)号：EP2046775A1

    公开(公告)日：2009-04-15

    申请号：EP07823311.1

    申请日：2007-07-20

    申请人： Sanofi-Aventis

    发明人： DUBOIS, Laurent ,  EVANNO, Yannick ,  MALANDA, André

    IPC分类号： C07D401/12 ,  A61K31/435 ,  A61P25/00 ,  A61P29/00 ,  A61P17/00 ,  A61P3/00 ,  A61P15/00 ,  A61P13/00 ,  A61P31/00 ,  A61P11/00

    CPC分类号： C07D401/12

    摘要： The invention relates to compounds of general formula (I): in which X1 is a hydrogen or halogen atom or a (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)-alkylene, (C1-C6)-fluoroalkyl, cyano, C(O)NR1R2, nitro, (C1-C6)-thioalkyl, -S(O)-(C1-C6)-alkyl, -S(O)2-(C1-C6)-alkyl, SO2NR1R2, aryl-(C1-C6)-alkylene, aryl or heteroaryl group, the aryl and the heteroaryl being optionally substituted; X2 is a hydrogen or halogen atom or a (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)-alkylene, (C1-C6)-fluoroalkyl, (C1-C6)-alkoxyl, (C3-C7)-cycloalkyl-(C1-C6)-alkylene-O-, (C1-C6)-fluoroalkoxyl, cyano, C(O)NR1R2, (C1-C6)-thioalkyl, -S(O)-(C1-C6)-alkyl, -S(O)2-(C1-C6)-alkyl, SO2NR1R2, aryl-(C1-C6)-alkylene, aryl or heteroaryl group, the aryl and the heteroaryl being optionally substituted; X3 and X4 are, independently of one another, a hydrogen or halogen atom or a (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)-alkylene, (C1-C6)-fluoroalkyl, (C1-C6)-alkoxyl, (C3-C7)-cycloalkyl-(C1-C6)-alkylene-O-, (C1-C6)-fluoroalkoxyl, cyano, C(O)NR1R2, nitro, NR1R2, (C1-C6)-thioalkyl, -S(O)-(C1-C6)-alkyl, -S(O)2-(C1-C6)-alkyl, SO2NR1R2, NR3COR4, NR3SO2R5, aryl-(C1-C6)-alkylene, aryl or heteroaryl group, the aryl and the heteroaryl being optionally substituted; Z1, Z2, Z3 and Z4 are, independently of one another, a nitrogen atom or a C(R6) group; n is equal to 0, 1, 2 or 3; Y is an optionally substituted aryl or heteroaryl; Ra and Rb are, independently of one another, a hydrogen atom or a (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl-(C1-C3)-alkylene, (C1-C6)-fluoroalkyl, hydroxyl, (C1-C6)-alkoxyl, (C3-C7)-cycloalkyl-(C1-C6)-alkylene-O-, (C1-C6)-fluoroalkoxyl, aryl or heteroaryl group, wherein Ra and Rb may be optionally substituted; in the form of a base or an addition salt with an acid, and also in the form of a hydrate or of a solvate. Process for the preparation thereof and therapeutic use.