发明公开
EP2133355A1 COMPOSITION CONTAINING CHLOROMETHYL PHOSPHATE DERIVATIVE WITH IMPROVED STABILITY AND METHOD FOR PRODUCING THE SAME
审中-公开
与改善稳定性和处理CHLORMETYHLPHOSPHAT衍生物组合物及其
- 专利标题： COMPOSITION CONTAINING CHLOROMETHYL PHOSPHATE DERIVATIVE WITH IMPROVED STABILITY AND METHOD FOR PRODUCING THE SAME
- 专利标题（中）： 与改善稳定性和处理CHLORMETYHLPHOSPHAT衍生物组合物及其
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申请号： EP08721325.2申请日： 2008-03-05
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公开(公告)号： EP2133355A1公开(公告)日： 2009-12-16
- 发明人: SATO, Keizo , ABE, Shinya , YOSHIZAWA, Kazuhiro , WAKASUGI, Kazunori , NEGI, Shigeto , MIYAZAWA, Mamoru
- 申请人： Eisai R&D Management Co., Ltd.
- 申请人地址： 6-10, Koishikawa 4-chome Bunkyo-Ku Tokyo 112-8088 JP
- 专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人地址： 6-10, Koishikawa 4-chome Bunkyo-Ku Tokyo 112-8088 JP
- 代理机构： HOFFMANN EITLE
- 优先权： JP2007056003 20070306
- 国际公布： WO2008108384 20080912
- 主分类号： C07F9/09
- IPC分类号： C07F9/09
摘要：
The present invention provides a process or the like which is employed for producing chloromethyl phosphate derivatives that are useful for producing water-soluble prodrugs, and which are excellent from the points of view of workability, operativity and energy saving. According to the present invention, there is provided a process for producing a composition containing a compound represented by the following formula (I) and a tertiary amine,
(wherein R1 and R2 are identical or different from each other, and represent a C1-C6 alkyl group, a C2-C6 alkenyl group or a C6-C14 aryl C1-C6 alkyl group which may have a substituent, and R1 and R2 may together form a ring), the proces comprising the step of adding the tertiary amine having a boiling point at 1 atmosphere of 150°C or higher to the compound represented by formula (I).
(wherein R1 and R2 are identical or different from each other, and represent a C1-C6 alkyl group, a C2-C6 alkenyl group or a C6-C14 aryl C1-C6 alkyl group which may have a substituent, and R1 and R2 may together form a ring), the proces comprising the step of adding the tertiary amine having a boiling point at 1 atmosphere of 150°C or higher to the compound represented by formula (I).
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