发明公开
EP2135867A1 Trans-9, 10-dehydroepothilone C and trans-9, 10-dehydroepothilone D, analogs thereof and methods of making the same
有权
反-9,10-脱氢山梨醇和反式-9,10-脱氢表面活性剂D，Analoga davon und Verfahren zu deren Herstellung
- 专利标题： Trans-9, 10-dehydroepothilone C and trans-9, 10-dehydroepothilone D, analogs thereof and methods of making the same
- 专利标题（中）： 反-9,10-脱氢山梨醇和反式-9,10-脱氢表面活性剂D，Analoga davon und Verfahren zu deren Herstellung
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申请号： EP09012671.5申请日： 2003-11-07
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公开(公告)号： EP2135867A1公开(公告)日： 2009-12-23
- 发明人: Li, Yong , Sundermann, Kurt , Tang, Li , Myles, David
- 申请人： Kosan Biosciences Incorporated
- 申请人地址： 3832 Bay Center Place Hayward, CA 94545 US
- 专利权人： Kosan Biosciences Incorporated
- 当前专利权人： Kosan Biosciences Incorporated
- 当前专利权人地址： 3832 Bay Center Place Hayward, CA 94545 US
- 代理机构： Beacham, Annabel Rose
- 优先权： US425352P 20021107; US473743 20030527
- 主分类号： C07D417/06
- IPC分类号： C07D417/06 ; C07D413/06 ; C07D405/06 ; A61K31/427 ; A61P35/00
摘要：
The present invention provides new trans -9,10-dehydroepothilone C and trans- 9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo . Also disclosed are methods of making the compounds.
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