发明公开
- 专利标题： AURORA KINASE MODULATORS AND METHOD OF USE
- 专利标题（中）： 极光激酶调制器和使用方法
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申请号： EP08742582.3申请日： 2008-04-03
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公开(公告)号： EP2137177A2公开(公告)日： 2009-12-30
- 发明人: CEE, Victor, J. , DEAK, Holly, L. , GEUNS-MEYER, Stephanie, D. , DU, Bingfan , HODOUS, Brian, L. , MARTIN, Matthew, W. , NGUYEN, Hanh, Nho , OLIVIERI, Philip, R. , PANTER, Kathleen , ROMERO, Karina , SCHENKEL, Laurie , WHITE, Ryan
- 申请人： Amgen, Inc
- 申请人地址： One Amgen Center Drive Thousand Oaks CA 91320 US
- 专利权人： Amgen, Inc
- 当前专利权人： Amgen, Inc
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks CA 91320 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： US922205P 20070405
- 国际公布： WO2008124083 20081016
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D409/04 ; C07D471/04 ; C07D487/04 ; C07D493/04 ; C07D495/04 ; A61K31/502 ; A61P35/00
摘要：
The present invention relates to chemical compounds having a general formula (I), wherein A1-8, D,, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.
公开/授权文献
- EP2137177B1 AURORA KINASE MODULATORS AND METHOD OF USE 公开/授权日：2014-05-07
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