发明公开
- 专利标题： INDOLE CARBOXAMIDES AS IKK2 INHIBITORS
- 专利标题（中）： 吲哚羧酰胺类作为IKK2抑制剂
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申请号： EP08732525.4申请日： 2008-03-20
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公开(公告)号： EP2139322A1公开(公告)日： 2010-01-06
- 发明人: BOEHM, Jeffrey, Charles , BUSCH-PETERSEN, Jakob , FU, Wei , JIN, Qi , KERNS, Jeffrey, K. , LI, Huijie , LIN, Guoliang , LIN, Xichen , NEIPP, Christopher, E.
- 申请人： Smithkline Beecham Corporation
- 申请人地址： One Franklin Plaza PO Box 7929 Philadelphia, PA 19101 US
- 专利权人： Smithkline Beecham Corporation
- 当前专利权人： Smithkline Beecham Corporation
- 当前专利权人地址： One Franklin Plaza PO Box 7929 Philadelphia, PA 19101 US
- 代理机构： Cooke, Tracey
- 优先权： US896558P 20070323
- 国际公布： WO2008118724 20081002
- 主分类号： A01N43/38
- IPC分类号： A01N43/38 ; A61K31/405
摘要：
The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
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