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公开(公告)号：EP1261336A2
公开(公告)日：2002-12-04
申请号：EP01918542.0
申请日：2001-03-09
发明人： WIDDOWSON, Katherine, L. , JIN, Qi
IPC分类号： A61K31/415 , A61K31/4192 , A61K31/42 , A61K31/4365 , A61K31/44 , A61K31/4406 , A61K31/513 , C07D213/74 , C07D213/75 , C07D231/38 , C07D231/40 , C07D237/20 , C07D249/06 , C07D261/02 , C07D261/04 , C07D497/04
CPC分类号： C07D213/75 , C07D213/89 , C07D231/40 , C07D249/04 , C07D249/14 , C07D261/14 , C07D495/04
摘要： This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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公开(公告)号：EP1605944A2
公开(公告)日：2005-12-21
申请号：EP04706441.5
申请日：2004-01-29
发明人： KERNS, Jeffrey , JIN, Qi , YAN, Hongxing , WAN, Zehong
IPC分类号： A61K31/496 , C07D401/06
CPC分类号： C07D401/06
摘要： Compounds of the formula (I) are disclosed which are NK2 and NK3 receptor antagonists and are useful in the treatment of respiratory diseases: or a pharmaceutically acceptable salt thereof.
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公开(公告)号：EP1539178A2
公开(公告)日：2005-06-15
申请号：EP03751880.0
申请日：2003-08-22
发明人： BONDINELL, William, E. , HALL, Ralph, F. , JIN, Qi , KERNS, Jeffrey, K. , NIE, Hong , WIDDOWSON, Katherine, L.
IPC分类号： A61K31/55 , A61P31/00 , C07D223/08 , C07D401/00 , C07D403/00 , C07D405/00 , C07D413/00 , C07D415/00 , C07D417/00 , C07D419/00
CPC分类号： H04L27/2601 , C07D223/08 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04
摘要： This invention relates 4-amino-azepan-3-ones of formula (1) which are useful as protease inhibitors, particularly of cathepsin S, and as such are useful for preventing a number of diseases amongst which are atherosclerotic lesions and pulmonary diseases such as asthma and allergic reactions.
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公开(公告)号：EP1261336B1
公开(公告)日：2007-02-07
申请号：EP01918542.0
申请日：2001-03-09
发明人： WIDDOWSON, Katherine, L. , JIN, Qi
IPC分类号： A61K31/415 , A61K31/4192 , A61K31/42 , A61K31/4365 , A61K31/44 , A61K31/4406 , A61K31/513 , C07D213/74 , C07D213/75 , C07D231/38 , C07D231/40 , A61P29/00
CPC分类号： C07D213/75 , C07D213/89 , C07D231/40 , C07D249/04 , C07D249/14 , C07D261/14 , C07D495/04
摘要： This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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公开(公告)号：EP1601360A2
公开(公告)日：2005-12-07
申请号：EP04706434.0
申请日：2004-01-29
发明人： KERNS, Jeffrey , JIN, Qi , WAN, Zehong , NIE, Hong , ZHU, Chongjie
IPC分类号： A61K31/496 , A61K31/5377 , C07D401/06 , C07D403/14 , C07D413/14
CPC分类号： C07D409/14
摘要： Compounds of formula (I) are disclosed which are NK2 and NK3 receptor antagonists and are useful in the treatment of respiratory diseases, or a pharmaceutically acceptable salt thereof.
摘要翻译： 公开了式（I）化合物，它们是NK2和NK3受体拮抗剂并可用于治疗呼吸系统疾病，或其药学上可接受的盐。
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公开(公告)号：EP1333833A2
公开(公告)日：2003-08-13
申请号：EP01994463.6
申请日：2001-10-23
发明人： ADAMS, Jerry, L. , BOEHM, Jeffrey, C. , HALL, Ralph , JIN, Qi , KASPAREC, Jiri , SILVA, Domingos, J. , TAGGART, John, J.
IPC分类号： A61K31/505 , A61P19/00 , A61P31/00 , C07D239/02 , C07D471/02
CPC分类号： C07D239/47 , C07D471/04
摘要： Novel substituted 2,4,8-trisubstituted -8H-pyrido[2,3-d]pyrimidin-7-one compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
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公开(公告)号：EP1274415A2
公开(公告)日：2003-01-15
申请号：EP01918675.8
申请日：2001-03-14
发明人： WIDDOWSON, Katherine, L. , JIN, Qi
IPC分类号： A61K31/18 , A61K31/196 , A61K31/277 , C07C311/47
CPC分类号： C07C311/47
摘要： This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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公开(公告)号：EP1896014A2
公开(公告)日：2008-03-12
申请号：EP06785861.3
申请日：2006-06-28
发明人： DENG, Jianghe , KERNS, Jeffrey, K. , JIN, Qi , LIN, Guoliang , LIN, Xichen , LINDENMUTH, Michael , NEIPP, Christopher, E. , NIE, Hong , THOMAS, Sonia, M. , WIDDOWSON, Katherine, L.
IPC分类号： A61K31/404 , A61K31/435 , C07D221/02
CPC分类号： C07D409/14 , C07D209/14 , C07D401/04 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: Formula (I) where R1 , R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译： 本发明涉及新的吲哚甲酰胺衍生物。 具体而言，本发明涉及根据式I的化合物：其中R 1，R 2，R 3，U和V如下定义的式（I）及其药学上可接受的盐。 本发明的化合物是IKK2的抑制剂，并且可用于治疗与不适当的IKK2（也称为IKKβ）活性相关的病症，例如类风湿性关节炎，哮喘和COPD（慢性阻塞性肺病）。 因此，本发明还涉及包含本发明化合物的药物组合物。 本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物抑制IKK2活性和治疗与之相关的病症的方法。
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公开(公告)号：EP1263427A1
公开(公告)日：2002-12-11
申请号：EP01924195.9
申请日：2001-03-16
发明人： WIDDOWSON, Katherine, L. , JIN, Qi
IPC分类号： A61K31/17 , A61K31/35 , A61K31/445 , A61K31/495 , C07C211/56 , C07C241/04 , C07C275/30 , C07C275/32 , C07C275/40 , C07C315/00
CPC分类号： C07D295/26 , C07C311/47 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2603/74 , C07D307/22 , C07D309/14
摘要： This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
摘要翻译： 本发明涉及式（I）至（VII）的新化合物及其组合物，其可用于治疗由趋化因子介导的疾病状态，白细胞介素-8（IL-8）。
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公开(公告)号：EP1161232A1
公开(公告)日：2001-12-12
申请号：EP99965288.6
申请日：1999-12-15
IPC分类号： A61K31/17 , A61K31/40 , A61K31/54 , A61K31/445 , A61K31/535 , C07C273/00 , C07C275/00 , C07D207/10 , C07D207/22 , C07D207/34 , C07D211/80 , C07D215/16 , C07D215/20 , C07D215/36 , C07D265/30 , C07D295/00
CPC分类号： C07D213/76 , C07C311/47 , C07C317/28 , C07C323/49 , C07C2601/02 , C07C2601/08 , C07D205/04 , C07D207/48 , C07D211/28 , C07D241/04 , C07D261/02 , C07D295/26 , C07D307/14
摘要： The invention relates to novel hydroxy diphenylurea sulfonamides, compositions and intermediates thereof. The hydroxy diphenylurea sulfonamides are useful in the treatment of disease states mediated by the chemokine, Interleukin-8.
摘要翻译： 本发明涉及新型羟基二苯基脲磺酰胺，其组合物和中间体。 羟基二苯基脲磺酰胺可用于治疗由趋化因子白细胞介素-8介导的疾病状态。
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