发明公开
- 专利标题： POLY (AMINO ACID) TARGETING MOIETIES
- 专利标题（中）： POLY（AMINSÄURE）-ZIELMOLEKÜLE
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申请号： EP08745171.2申请日： 2008-04-04
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公开(公告)号： EP2144600A2公开(公告)日： 2010-01-20
- 发明人: ALEXIS, Frank , ZHANG, Liangfang , RADOVIC-MORENO, Aleksandar, F. , GU, Frank, X. , BASTO, Pamela , LEVY-NISSENBAUM, Etgar , CHAN, Juliana , LANGER, Robert, S. , FAROKHZAD, Omid, C.
- 申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , The Brigham and Women's Hospital, Inc.
- 申请人地址： 5 Cambridge Center, Room NE25-230 Kendall Square, Cambridge, MA 02142 US
- 专利权人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY,The Brigham and Women's Hospital, Inc.
- 当前专利权人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY,The Brigham and Women's Hospital, Inc.
- 当前专利权人地址： 5 Cambridge Center, Room NE25-230 Kendall Square, Cambridge, MA 02142 US
- 代理机构： Harris, Jennifer Lucy
- 优先权： US910097P 20070404; US938590P 20070517; US985104P 20071102; US986202P 20071107; US990250P 20071126
- 国际公布： WO2008124639 20081016
- 主分类号： A61K9/16
- IPC分类号： A61K9/16
摘要：
The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
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