发明公开
- 专利标题： Hydroxyalkyl starch derivatives
- 专利标题（中）： 羟烷基淀粉衍生物
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申请号： EP09014352.0申请日： 2003-09-11
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公开(公告)号： EP2154160A1公开(公告)日： 2010-02-17
- 发明人: Zander, Norbert , Eichner, Wolfram , Conradt, Harald
- 申请人： Fresenius Kabi Deutschland GmbH
- 申请人地址： Else-Kröner-Strasse 1 61352 Bad Homburg DE
- 专利权人： Fresenius Kabi Deutschland GmbH
- 当前专利权人： Fresenius Kabi Deutschland GmbH
- 当前专利权人地址： Else-Kröner-Strasse 1 61352 Bad Homburg DE
- 代理机构： Wichmann, Hendrik
- 优先权： EP02020425 20020911; US409781P 20020911; PCT/EP03/08859 20030808
- 主分类号： C08B31/12
- IPC分类号： C08B31/12 ; A61K47/48 ; C07K14/505 ; C07K17/10
摘要：
The present invention relates to a method of producing a hydroxyalkyl starch derivative comprising reacting hydroxyalkyl starch of formula (I)
at its reducing end which is not oxidized prior to said reaction, with a compound of formula (II)
R'-NH-R" (II)
wherein R 1 , R 2 and R 3 are independently hydrogen or a linear or branched hydroxyalkyl group, and wherein either R' or R" or R' and R" comprise at least one functional group X capable of being reacted with at least one other compound prior to or after the reaction of (I) and (II), as well as to the hydroxyalkyl starch derivative as such, obtainable by said method, and to a pharmaceutical composition comprising said hydroxyalkyl starch derivative.
at its reducing end which is not oxidized prior to said reaction, with a compound of formula (II)
R'-NH-R" (II)
wherein R 1 , R 2 and R 3 are independently hydrogen or a linear or branched hydroxyalkyl group, and wherein either R' or R" or R' and R" comprise at least one functional group X capable of being reacted with at least one other compound prior to or after the reaction of (I) and (II), as well as to the hydroxyalkyl starch derivative as such, obtainable by said method, and to a pharmaceutical composition comprising said hydroxyalkyl starch derivative.
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