发明公开
EP2163249A1 INFUSION SOLUTION FOR PERIPHERAL INTRAVENOUS ADMINISTRATION
审中-公开
INFUSIONSLÖSUNGZUR PERIPHERENINTRAVENÖSENVERABREICHUNG
- 专利标题: INFUSION SOLUTION FOR PERIPHERAL INTRAVENOUS ADMINISTRATION
- 专利标题(中): INFUSIONSLÖSUNGZUR PERIPHERENINTRAVENÖSENVERABREICHUNG
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申请号: EP08764571.9申请日: 2008-05-23
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公开(公告)号: EP2163249A1公开(公告)日: 2010-03-17
- 发明人: SHIGETA, Mutsuo , ABIKO, Kazuhiro
- 申请人: Ajinomoto Co., Inc.
- 申请人地址: 15-1, Kyobashi 1-chome Chuo-ku Tokyo 104-8315 JP
- 专利权人: Ajinomoto Co., Inc.
- 当前专利权人: Ajinomoto Co., Inc.
- 当前专利权人地址: 15-1, Kyobashi 1-chome Chuo-ku Tokyo 104-8315 JP
- 代理机构: Nicholls, Kathryn Margaret
- 优先权: JP2007138604 20070525
- 国际公布: WO2008146732 20081204
- 主分类号: A61K31/7004
- IPC分类号: A61K31/7004 ; A61K9/08 ; A61K31/19 ; A61K31/191 ; A61K31/198 ; A61K31/51 ; A61K47/02 ; A61K47/12 ; A61K47/20 ; A61K47/22 ; A61K47/26 ; A61P3/02
摘要:
There is provided an infusion solution for peripheral intravenous administration comprising a multichamber vessel constructed in a connectable manner, which separately houses a sugar solution containing sugars, electrolytes and vitamin B1, and an amino acid solution containing amino acids, electrolytes and a sulfite, whereby the vitamin B1 and amino acids are stably maintained.
In the infusion solution for peripheral intravenous administration, the sugar solution contains calcium gluconate, contains no greater than 1.4 g/L sodium lactate, has a pH of 4.0-4.7 and has a titratable acidity of 2-4, the amino acid solution contains 4.0-8.0 g/L sodium lactate, contains no calcium gluconate, has a pH of 6.8-7.2, contains free L-cysteine as cysteine and contains 0.05-0.2 g/L sodium hydrogen sulfite, and after the sugar solution and amino acid solution have been mixed, the infusion solution has a pH of 6.5-7.1 and a titratable acidity of 5-10.
In the infusion solution for peripheral intravenous administration, the sugar solution contains calcium gluconate, contains no greater than 1.4 g/L sodium lactate, has a pH of 4.0-4.7 and has a titratable acidity of 2-4, the amino acid solution contains 4.0-8.0 g/L sodium lactate, contains no calcium gluconate, has a pH of 6.8-7.2, contains free L-cysteine as cysteine and contains 0.05-0.2 g/L sodium hydrogen sulfite, and after the sugar solution and amino acid solution have been mixed, the infusion solution has a pH of 6.5-7.1 and a titratable acidity of 5-10.
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