公开(公告)号：EP2163249A1

公开(公告)日：2010-03-17

申请号：EP08764571.9

申请日：2008-05-23

申请人： Ajinomoto Co., Inc.

发明人： SHIGETA, Mutsuo ,  ABIKO, Kazuhiro

IPC分类号： A61K31/7004 ,  A61K9/08 ,  A61K31/19 ,  A61K31/191 ,  A61K31/198 ,  A61K31/51 ,  A61K47/02 ,  A61K47/12 ,  A61K47/20 ,  A61K47/22 ,  A61K47/26 ,  A61P3/02

CPC分类号： A61K9/0019 ,  A61K31/19 ,  A61K31/191 ,  A61K31/198 ,  A61K31/51 ,  A61K31/7004 ,  A61K47/02 ,  A61K47/26

摘要： There is provided an infusion solution for peripheral intravenous administration comprising a multichamber vessel constructed in a connectable manner, which separately houses a sugar solution containing sugars, electrolytes and vitamin B1, and an amino acid solution containing amino acids, electrolytes and a sulfite, whereby the vitamin B1 and amino acids are stably maintained.
In the infusion solution for peripheral intravenous administration, the sugar solution contains calcium gluconate, contains no greater than 1.4 g/L sodium lactate, has a pH of 4.0-4.7 and has a titratable acidity of 2-4, the amino acid solution contains 4.0-8.0 g/L sodium lactate, contains no calcium gluconate, has a pH of 6.8-7.2, contains free L-cysteine as cysteine and contains 0.05-0.2 g/L sodium hydrogen sulfite, and after the sugar solution and amino acid solution have been mixed, the infusion solution has a pH of 6.5-7.1 and a titratable acidity of 5-10.

摘要翻译： 提供了一种用于外周静脉内施用的输注溶液，其包括以可连接的方式构建的多室容器，其分开容纳含有糖，电解质和维生素B1的糖溶液以及含有氨基酸，电解质和亚硫酸盐的氨基酸溶液，由此 维生素B1和氨基酸稳定保持。 在用于外周静脉内给药的输液中，糖溶液含有葡萄糖酸钙，含有不大于1.4g / L乳酸钠，pH值为4.0-4.7，滴定酸度为2-4，氨基酸溶液含有4.0 -8.0 g / L乳酸钠，不含葡萄糖酸钙，pH值为6.8-7.2，含有游离L-半胱氨酸作为半胱氨酸，含有0.05-0.2 g / L亚硫酸氢钠，糖溶液和氨基酸溶液后 输液溶液的pH值为6.5-7.1，滴定酸度为5-10。