发明公开
EP2166006A1 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
审中-公开
2-Arylpropionsäurenund -Derivate und pharmazeutische Zusammensetzungen，die diese enthalten
- 专利标题： 2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
- 专利标题（中）： 2-Arylpropionsäurenund -Derivate und pharmazeutische Zusammensetzungen，die diese enthalten
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申请号： EP08164605.1申请日： 2008-09-18
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公开(公告)号： EP2166006A1公开(公告)日： 2010-03-24
- 发明人: Allegretti, Marcello , Aramini, Andrea , Bianchini, Gianluca , Cesta, Maria Candida
- 申请人： Dompe' S.P.A.
- 申请人地址： Località Campo di Pile sne 67100 L'Aquila IT
- 专利权人： Dompe' S.P.A.
- 当前专利权人： Dompe' S.P.A.
- 当前专利权人地址： Località Campo di Pile sne 67100 L'Aquila IT
- 代理机构： Fiorani, Giuseppe
- 主分类号： C07D263/48
- IPC分类号： C07D263/48 ; C07D277/42 ; A61K31/427 ; A61K31/421 ; A61P29/00
摘要：
The present invention relates to (R,S) 2-aryl-propionic acids and derivatives, their single enantiomer (S) and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonucleated neutrophils (PMN leukocytes) at inflammation sites.
The present invention provides compounds for use in the treatment of transient cerebral ischemia, bullous pcmphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and damages caused by ischemia and reperfusion.
The present invention provides compounds for use in the treatment of transient cerebral ischemia, bullous pcmphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and damages caused by ischemia and reperfusion.
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