发明公开
- 专利标题： MUTATED E. COLI HEAT-LABILE ENTEROTOXIN
- 专利标题（中）： 突变HITZELABILES大肠杆菌肠毒素
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申请号： EP07868328申请日： 2007-08-13
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公开(公告)号： EP2170377A4公开(公告)日： 2010-12-29
- 发明人: HSU YU-SHEN , LIN YOUNG-SUN , YUAN TA-TUNG
- 申请人： DEV CENTER BIOTECHNOLOGY
- 专利权人： DEV CENTER BIOTECHNOLOGY
- 当前专利权人： DEV CENTER BIOTECHNOLOGY
- 优先权： US77941907 2007-07-18
- 主分类号： A61K39/02
- IPC分类号： A61K39/02 ; C07K14/425
摘要：
This invention relates to a mutant E. coli heat-labile enterotoxin (LT) subunit A that can be used as an adjuvant. This subunit A mutant contains an amino acid substitution at a position corresponding to position 61 of a wild-type LT. An LT containing this mutated subunit A exhibits reduced toxicity compared to its wild type counterpart.
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