发明公开
EP2170865A2 INDAZOLES SUBSTITUES, LEUR PREPARATION ET LEUR UTILISATION EN THERAPEUTIQUE
审中-公开
新的取代的吲唑和其生产和使用治疗剂
- 专利标题: INDAZOLES SUBSTITUES, LEUR PREPARATION ET LEUR UTILISATION EN THERAPEUTIQUE
- 专利标题(英): Novel substituted indazoles, the preparation thereof, and use of same in therapeutics
- 专利标题(中): 新的取代的吲唑和其生产和使用治疗剂
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申请号: EP08826411.4申请日: 2008-06-18
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公开(公告)号: EP2170865A2公开(公告)日: 2010-04-07
- 发明人: ALETRU, Michel , DAMOUR, Dominique , MONSEAU, Catherine , MOUGENOT, Patrick , NAMANE, Claudie , NARDI, Frederico , NEMECEK, Patrick , PHILIPPO, Christophe
- 申请人: Sanofi-Aventis
- 申请人地址: 174 Avenue de France 75013 Paris FR
- 专利权人: Sanofi-Aventis
- 当前专利权人: Sanofi-Aventis
- 当前专利权人地址: 174 Avenue de France 75013 Paris FR
- 代理机构: Le Pennec, Magali
- 优先权: FR0704422 20070621
- 国际公布: WO2009010660 20090122
- 主分类号: C07D401/12
- IPC分类号: C07D401/12 ; C07D401/14 ; A61K31/416
摘要:
The invention relates to compounds of formula (I) wherein: E is a grouping (i) of formula -NT-CO-O- or -NT-CX-NT'- wherein X is =O or =S and T and T', that can be identical or different and selected independently, from H or an alkyl group, or (ii) forming a five-membered or six-membered ring bound in position 5 or 6 of the indazole nucleus by -NT- or by the nitrogen atom N1; R1 is at least one substituent selected independently when there are several, and being a halogen atom, an alkyl, alkenyl, alkynyl, halogenoalkyl, halogenoalcoxy, aryl, heteroaryl, heterocycloalkyl, cycloalkyl, CN, NRR', OR, NO2, COOR, CONRR', or NRCOR' group; R2 is a hydrogen atom, or an alkyl, alkenyl or alkynyl group; R3 is at least one substituent selected independently when there are several, and being a hydrogen atom, an alkyl, alkenyl, alkynyl, halogenoalcoxy, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NRR', CF3, OR, NO2, COOR, CONRR', or NRCOR' group; R4 is a hydrogen atom or a halogen atom, an alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycloalkyl, -NR-CO-R', COOR, NRR', CHO, or CONR(OR') group; R and R' are identical or different and are independently a hydrogen atom, or an alkyl, aryl, heterocycloalkyl, cycloalkyl or heteroaryl group; and n1 is a whole number between 0 and 5, and n3 is a whole number between 0 and 3.
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