公开(公告)号：EP1699454B1

公开(公告)日：2009-08-05

申请号：EP04806274.9

申请日：2004-12-15

申请人： Sanofi-Aventis

发明人： ALETRU, Michel ,  ARÁNYI, Péter ,  BALOGH, Mária ,  BÁTORI, Sándor ,  BENCE, Judit ,  BOVY, Philippe ,  KAPUI, Zoltán ,  MIKUS, Endre ,  NAMANE, Claudie ,  PHILIPPO, Christophe ,  SZABÓ, Tibor ,  TÖMÖSKÖZI, Zsuzsanna ,  URBÁN-SZABÓ, Katalin

IPC分类号： A61K31/415 ,  A61K31/4155 ,  C07D401/12 ,  C07D231/16 ,  C07D471/04 ,  C07D413/12 ,  C07D403/12 ,  C07D417/12 ,  C07D401/04 ,  C07D401/14 ,  C07D409/12 ,  C07D409/14 ,  A61P1/14 ,  A61P25/00

CPC分类号： C07D409/04 ,  C07D231/16 ,  C07D231/56 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.

公开(公告)号：EP2044057A2

公开(公告)日：2009-04-08

申请号：EP07803781.9

申请日：2007-06-26

申请人： Sanofi-Aventis

发明人： BRAUN, Alain ,  GUSSREGEN Stefan ,  MOUGENOT, Patrick ,  NAMANE, Claudie ,  NICOLAI, Eric ,  PACQUET, François ,  PHILIPPO, Christophe ,  VENIER, Olivier ,  CRESPIN, Olivier ,  PASCAL, Cécile ,  ALETRU, Michel

IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D401/06 ,  C07D417/14 ,  A61K31/4709 ,  A61K31/536 ,  A61P3/00

CPC分类号： C07D401/14 ,  C07D401/06 ,  C07D403/06 ,  C07D403/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/14

摘要： The invention concerns compounds corresponding to formula (I) in which R1a, R1b, R1c, R1d, R2a, R2b, R2c, R2d, R3a, R3b, R4, n, i, j, o, p, q, r and X are as defined in the description. Preparation method and therapeutic use.

公开(公告)号：EP2170865A2

公开(公告)日：2010-04-07

申请号：EP08826411.4

申请日：2008-06-18

申请人： Sanofi-Aventis

发明人： ALETRU, Michel ,  DAMOUR, Dominique ,  MONSEAU, Catherine ,  MOUGENOT, Patrick ,  NAMANE, Claudie ,  NARDI, Frederico ,  NEMECEK, Patrick ,  PHILIPPO, Christophe

IPC分类号： C07D401/12 ,  C07D401/14 ,  A61K31/416

CPC分类号： C07D401/14 ,  C07D401/12

摘要： The invention relates to compounds of formula (I) wherein: E is a grouping (i) of formula -NT-CO-O- or -NT-CX-NT'- wherein X is =O or =S and T and T', that can be identical or different and selected independently, from H or an alkyl group, or (ii) forming a five-membered or six-membered ring bound in position 5 or 6 of the indazole nucleus by -NT- or by the nitrogen atom N1; R1 is at least one substituent selected independently when there are several, and being a halogen atom, an alkyl, alkenyl, alkynyl, halogenoalkyl, halogenoalcoxy, aryl, heteroaryl, heterocycloalkyl, cycloalkyl, CN, NRR', OR, NO2, COOR, CONRR', or NRCOR' group; R2 is a hydrogen atom, or an alkyl, alkenyl or alkynyl group; R3 is at least one substituent selected independently when there are several, and being a hydrogen atom, an alkyl, alkenyl, alkynyl, halogenoalcoxy, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NRR', CF3, OR, NO2, COOR, CONRR', or NRCOR' group; R4 is a hydrogen atom or a halogen atom, an alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycloalkyl, -NR-CO-R', COOR, NRR', CHO, or CONR(OR') group; R and R' are identical or different and are independently a hydrogen atom, or an alkyl, aryl, heterocycloalkyl, cycloalkyl or heteroaryl group; and n1 is a whole number between 0 and 5, and n3 is a whole number between 0 and 3.

公开(公告)号：EP1699454A1

公开(公告)日：2006-09-13

申请号：EP04806274.9

申请日：2004-12-15

申请人： Sanofi-Aventis

发明人： ALETRU, Michel ,  ARÁNYI, Péter ,  BALOGH, Mária ,  BÁTORI, Sándor ,  BENCE, Judit ,  BOVY, Philippe ,  KAPUI, Zoltán ,  MIKUS, Endre ,  NAMANE, Claudie ,  PHILIPPO, Christophe ,  SZABÓ, Tibor ,  TÖMÖSKÖZI, Zsuzsanna ,  URBÁN-SZABÓ, Katalin

IPC分类号： A61K31/415 ,  A61K31/4155 ,  C07D401/12 ,  C07D231/16 ,  C07D471/04 ,  C07D413/12 ,  C07D403/12 ,  C07D417/12 ,  C07D401/04 ,  C07D401/14 ,  C07D409/12 ,  C07D409/14 ,  A61P1/14 ,  A61P25/00

CPC分类号： C07D409/04 ,  C07D231/16 ,  C07D231/56 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.