发明公开
EP2172449A2 Process for the purification of Anastrazole
审中-公开
Verfahren zur Reinigung von Anastrazol
- 专利标题： Process for the purification of Anastrazole
- 专利标题（中）： Verfahren zur Reinigung von Anastrazol
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申请号： EP09174323.7申请日： 2006-04-06
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公开(公告)号： EP2172449A2公开(公告)日： 2010-04-07
- 发明人: Villa, Marco , Fretta, Roberta , Diulgheroff, Nicola , Pontiroli, Alessandro
- 申请人： Sicor, Inc.
- 申请人地址： 19 Hughes Irvine, CA 92618 US
- 专利权人： Sicor, Inc.
- 当前专利权人： Sicor, Inc.
- 当前专利权人地址： 19 Hughes Irvine, CA 92618 US
- 代理机构： Russell, Tim
- 优先权： US669132P 20050406; US694528P 20050627
- 主分类号： C07C255/33
- IPC分类号： C07C255/33 ; C07D249/08 ; A61K31/4196 ; A61P35/00
摘要：
A process for purifying Anastrozole is provided. In the process the steps of
a. extracting a quenched reaction mixture containing anastrazole with a mixture of toluene, linear, branched or cyclic C 5-8 hydrocarbon and water;
b. extracting the aqueous phase using a mixture comprising of toluene and linear, branched or cyclic C 5-8 hydrocarbon;
c. adding water;
d. extracting the aqueous phase using toluene;
e. washing the organic phase with an aqueous solution of an acid;
f. adding linear, branched, or cyclic C 5-8 hydrocarbon to the organic phase to precipitate Anastrozole,
are performed.
a. extracting a quenched reaction mixture containing anastrazole with a mixture of toluene, linear, branched or cyclic C 5-8 hydrocarbon and water;
b. extracting the aqueous phase using a mixture comprising of toluene and linear, branched or cyclic C 5-8 hydrocarbon;
c. adding water;
d. extracting the aqueous phase using toluene;
e. washing the organic phase with an aqueous solution of an acid;
f. adding linear, branched, or cyclic C 5-8 hydrocarbon to the organic phase to precipitate Anastrozole,
are performed.
公开/授权文献
- EP2172449A3 Process for the purification of Anastrazole 公开/授权日：2011-06-22
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