公开(公告)号：EP4511025A1

公开(公告)日：2025-02-26

申请号：EP23792771.0

申请日：2023-04-20

Applicant: Engrail Therapeutics, Inc.

Inventor： SUDARSAN, Vikram ,  GARVEY, David ,  TAYLOR, Eve ,  MHASKAR, Sunil ,  BRUBAKER, William

IPC: A61K31/4196 ,  A61K31/395 ,  A61K31/424 ,  A61K31/50 ,  A61K31/33

公开(公告)号：EP4497439A1

公开(公告)日：2025-01-29

申请号：EP23382792.2

申请日：2023-07-28

Applicant: Universitat de les Illes Balears

Inventor： COSTA BAUZÀ, Antonia ,  GRASES FREIXEDAS, Felix

IPC: A61K31/522 ,  A61K31/165 ,  A61K31/195 ,  A61K31/343 ,  A61K31/4152 ,  A61K31/4196 ,  A61K31/426 ,  A61K31/519 ,  A61P19/02 ,  A61P19/06

Abstract: The present invention provides compound of formula (I) or a pharmaceutically acceptable salt thereof, for use in the prevention and/or treatment of a disease or disorder associated with the crystallization of monosodium urate monohydrate, wherein R 1 and R 2 are different and are selected from -H and -(C 1 -C 6 )alkyl; and R 3 is selected from -H and =O. The invention also provides an in vitro method for eliminating and/or preventing the formation of monosodium urate monohydrate crystals in a composition, and an i n vitro use of a compound of formula (I) for eliminating and/or preventing the formation of monosodium urate monohydrate crystals.

公开(公告)号：EP4491622A2

公开(公告)日：2025-01-15

申请号：EP24179234.0

申请日：2019-01-18

Applicant: Cytokinetics, Inc.

Inventor： CHUANG, Chihyuan ,  MORGAN, Bradley P. ,  VANDERWAL, Mark ,  WANG, Wenyue ,  ASHCRAFT, Luke W.

IPC: C07D403/12 ,  C07D413/14 ,  C07D231/14 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D271/06 ,  A61P9/04 ,  A61K31/4196

Abstract: Provided are compounds of Formula (I):

or a pharmaceutically acceptable salt thereof, wherein A, Z, B, R 1 , R 2 , R 3 , G 1 , G 2 ,and G 3 are as defined herein.
Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP4487911A1

公开(公告)日：2025-01-08

申请号：EP24174636.1

申请日：2020-07-16

Applicant: Cytokinetics, Inc.

Inventor： TOM,, Norma ,  PFEIFFER,, Matthew ,  ANDERSEN,, Denise ,  GAO,, Qi

IPC: A61P9/04 ,  C07D413/12 ,  A61K31/4196

Abstract: Provided herein are polymorphs of (R)-N-(5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)-1-methyl-1H-pyrazole-4-carboxamide, compositions thereof, methods of preparation thereof, and methods of their uses.

公开(公告)号：EP4424370A3

公开(公告)日：2024-12-25

申请号：EP24177200.3

申请日：2019-12-11

Applicant: F. Hoffmann-La Roche AG

Inventor： FREI, Beat ,  RATNI, Hasane

IPC: C07D487/04 ,  A61K31/4196 ,  A61K31/501 ,  A61K31/506 ,  A61K31/46 ,  A61P25/28 ,  A61P27/16

Abstract: The invention provides new bicyclic heteroaryl compounds having the general formula (I)

wherein R 1 , Ar, n and m are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：EP3641746B1

公开(公告)日：2024-11-20

申请号：EP18820949.8

申请日：2018-06-19

Inventor： ALMEIDA DE PINHO RIBEIRO, Felipe ,  BARAL, Pankaj ,  CHIU, Isaac M. ,  YANG, Nicole J. ,  WESSELS, Michael ,  BADDAL, Buket

IPC: C12N9/52 ,  A61K38/48 ,  A61K45/06 ,  A61K31/357 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/454 ,  A61K31/506 ,  A61K31/7088 ,  A61K38/22 ,  A61P31/00 ,  C07K14/575 ,  C07K16/18 ,  A61P31/04 ,  A61K9/00

公开(公告)号：EP4069690B1

公开(公告)日：2024-11-13

申请号：EP20824979.7

申请日：2020-12-04

Inventor： WALLIS, Christopher John ,  STEELE, Gerald ,  BUTTAR, Suzanne ,  SULEIMAN, Osama ,  NORTHEN, Julian ,  MYKYTIUK, John ,  MARSHALL, Jamie

IPC: C07D405/06 ,  A61K31/4196 ,  A61P31/10

公开(公告)号：EP4448101A1

公开(公告)日：2024-10-23

申请号：EP22843425.4

申请日：2022-12-15

Applicant: Immunyx Pharma Ltd.

Inventor： DRUMMOND, Daryl C ,  SALPETER, Seth Jonah

IPC: A61P29/00 ,  A61P35/00 ,  C07D249/08 ,  C07D401/10 ,  A61K31/4196 ,  A61K31/435

公开(公告)号：EP4436975A1

公开(公告)日：2024-10-02

申请号：EP22826778.7

申请日：2022-11-22

Applicant: GENENTECH, INC. ,  Convelo Therapeutics, Inc.

Inventor： BRAUN, Marie-Gabrielle ,  CASTANEDO, Georgette ,  VERNIER, William ,  VOLGRAF, Matthew ,  BREITENBUCHER, James Guy ,  LANG, Brad

IPC: C07D495/10 ,  A61P25/00 ,  A61K31/407 ,  A61K31/4155 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4196 ,  A61K31/506

CPC classification number: C07D495/10 ,  A61P25/00

公开(公告)号：EP3435993B1

公开(公告)日：2024-09-25

申请号：EP17716149.4

申请日：2017-04-03

IPC: A61K31/16 ,  A61P27/00 ,  A61P29/00 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/22 ,  A61K31/341 ,  A61K31/351 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/5375

CPC classification number: A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/22 ,  A61K31/341 ,  A61K31/351 ,  A61K31/40 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/5375 ,  A61P27/00 ,  A61P29/00