发明授权
EP2178873B1 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN INHIBITORS
有权
作为钙调蛋白抑制剂的6-苯基-1H-咪唑并[4,5-C]吡啶-4-碳腈衍生物
- 专利标题： 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN INHIBITORS
- 专利标题（中）： 作为钙调蛋白抑制剂的6-苯基-1H-咪唑并[4,5-C]吡啶-4-碳腈衍生物
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申请号： EP08786128.2申请日： 2008-07-14
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公开(公告)号： EP2178873B1公开(公告)日： 2010-12-22
- 发明人: CAI, Jiaqiang , RANKOVIC, Zoran , JONES, Philip, Stephen , BENNETT, David, Jonathan , FRADERA, Xavier
- 申请人： N.V. Organon
- 申请人地址： Kloosterstraat 6 5349 AB Oss NL
- 专利权人： N.V. Organon
- 当前专利权人： N.V. Organon
- 当前专利权人地址： Kloosterstraat 6 5349 AB Oss NL
- 代理机构： van Wezenbeek, Petrus M.G.F.
- 优先权： EP07112517 20070716
- 国际公布： WO2009010491 20090122
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61P19/00 ; A61P17/00 ; A61P29/00
摘要：
The present invention relates to 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives having the general Formula (I), to pharmaceutical compositions comprising the same as well as to the use of these derivatives for the preparation of a medicament for the treatment of cathepsin S related diseases such asatherosclerosis,obesity, inflammation and immune disorders, such as rheumatoid arthritis, psoriasis, cancer,and chronic pain, such as neuropathic pain.
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