发明公开
EP2185571A1 SUBSTITUTED ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF TYPE I AND II DIABETES MELLITUS
审中-公开
取代的芳基磺酰氨基亚甲基膦酸衍生物及其制备和它们在治疗I型和II型糖尿病中的用途
- 专利标题： SUBSTITUTED ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF TYPE I AND II DIABETES MELLITUS
- 专利标题（中）： 取代的芳基磺酰氨基亚甲基膦酸衍生物及其制备和它们在治疗I型和II型糖尿病中的用途
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申请号： EP08786464.1申请日： 2008-07-25
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公开(公告)号： EP2185571A1公开(公告)日： 2010-05-19
- 发明人: WAGNER, Holger , LANGKOPF, Elke , ECKHARDT, Matthias , STREICHER, Ruediger , SCHOELCH, Corinna , SCHULER-METZ, Annette , PAUTSCH, Alexander
- 申请人： Boehringer Ingelheim International GmbH
- 申请人地址： Binger Straße 173 55216 Ingelheim am Rhein DE
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： Binger Straße 173 55216 Ingelheim am Rhein DE
- 代理机构： Hammann, Heinz
- 优先权： DE102007035333 20070727
- 国际公布： WO2009016118 20090205
- 主分类号： C07F9/572
- IPC分类号： C07F9/572 ; C07F9/6503 ; C07F9/6506 ; C07F9/653 ; C07F9/6541 ; C07F9/6553 ; C07F9/6558 ; A61K31/67 ; A61K31/675 ; A61P3/10
摘要：
The present invention relates to substituted arylsulphonylaminomethylphosphonic acid derivatives of general formula (I) wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.
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