The invention relates to a system (100) for registering an atlas image from an atlas of multidimensional images with an objective image, the system comprising a generation unit (105) for generating a candidate transformation for transforming a first region of the atlas image, a transformation unit (110) for transforming the first region of the atlas image using the candidate transformation, a similarity unit (120) for computing a measure of similarity of the transformed first region of the atlas image and a corresponding first region of the objective image, an evaluation unit (130) for evaluating the candidate transformation using a criterion based on the computed measure of similarity and determining an optimal transformation based on the evaluation of the candidate transformation, an extension unit (140) for extending the optimal transformation of the first region of the atlas image to a second region of the atlas image, wherein the second region comprises the first region, thereby creating a registration transformation and a registration unit (150) for transforming the second region using the registration transformation, thereby registering the atlas image with the objective image. Advantageously, the system (100) does not require setting landmark positions in the objective image. A further advantage of the system (100) is that since the similarity measure is computed locally, i.e., based on the first region of the atlas image, the registration is fast and thus attractive for clinical use.