发明公开
EP2188272A2 PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
有权
苯基和BENZYLTHIAZOLYLPIPERAZINDERIVATE神经退行性疾病的治疗
- 专利标题： PHENYL- AND BENZYLTHIAZOLYLPIPERAZINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
- 专利标题（中）： 苯基和BENZYLTHIAZOLYLPIPERAZINDERIVATE神经退行性疾病的治疗
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申请号： EP08786967.3申请日： 2008-08-06
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公开(公告)号： EP2188272A2公开(公告)日： 2010-05-26
- 发明人: GRIFFIOEN, Gerard , ROJAS DE LA PARRA, Veronica , LAUWERS, Annick
- 申请人： NV Remynd
- 申请人地址： Gaston Geenslaan 1 3001 Heverlee BE
- 专利权人： NV Remynd
- 当前专利权人： NV Remynd
- 当前专利权人地址： Gaston Geenslaan 1 3001 Heverlee BE
- 代理机构： Bird, William Edward
- 优先权： GB0715257 20070806; GB0715256 20070806
- 国际公布： WO2009019295 20090212
- 主分类号： C07D277/42
- IPC分类号： C07D277/42 ; C07D417/06 ; C07D417/12 ; C07D417/04 ; A61K31/496 ; A61P25/28
摘要：
This invention provides phenyl- and benzyl-thiazolylpiperazine derivatives, and
N -sulfonyl heterocyclic derivatives including phenyl- and benzyl-thiazolylpiperidine derivatives, and pharmaceutically acceptable salts thereof, for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease.
N -sulfonyl heterocyclic derivatives including phenyl- and benzyl-thiazolylpiperidine derivatives, and pharmaceutically acceptable salts thereof, for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease.
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