公开(公告)号：EP1981504B1

公开(公告)日：2010-07-21

申请号：EP07711455.1

申请日：2007-02-07

申请人： NV reMYND

发明人： GRIFFIOEN, Gerard ,  COUPET, Kristel Marie Edith ,  DUHAMEL, Hein Roger ,  WERA, Stefaan ,  GOMME, Ellen ,  VAN DAMME, Nele ,  VAN DER AUWERA, Ingrid ,  LOX, Marleen ,  VAN DOOREN, Tom ,  DECRUY, Tine

IPC分类号： A61K31/496 ,  C07D285/12 ,  C07C257/14 ,  A61P25/00

CPC分类号： C07C257/14 ,  A61K31/496 ,  C07D285/08 ,  C07D285/125 ,  C07D285/135 ,  C07D417/12

公开(公告)号：EP2094677A1

公开(公告)日：2009-09-02

申请号：EP07846792.5

申请日：2007-11-22

申请人： NV Remynd

发明人： GRIFFIOEN, Gerard ,  WERA, Stefaan ,  DUHAMEL, Hein Roger ,  VAN DAMME, Niele ,  GOMME, Ellen

IPC分类号： C07D285/08 ,  A61K31/433 ,  A61P25/16 ,  A61P25/28

CPC分类号： C07D417/04 ,  C07D285/08 ,  C07D417/12

摘要： The invention provides novel 1,2,4-thiadiazole derivatives useful for preventing or treating an α-synucleopathy such as Parkinson's disease, as well as pharmaceutical compositions including them as biologically active ingredients, and methods for manufacturing them.

公开(公告)号：EP2094677B1

公开(公告)日：2011-01-12

申请号：EP07846792.5

申请日：2007-11-22

申请人： NV Remynd

发明人： GRIFFIOEN, Gerard ,  WERA, Stefaan ,  DUHAMEL, Hein Roger ,  VAN DAMME, Nele ,  GOMME, Ellen

IPC分类号： C07D285/08 ,  A61K31/433 ,  A61P25/16 ,  A61P25/28

CPC分类号： C07D417/04 ,  C07D285/08 ,  C07D417/12

摘要： The invention provides novel 1,2,4-thiadiazole derivatives useful for preventing or treating an α-synucleopathy such as Parkinson's disease, as well as pharmaceutical compositions including them as biologically active ingredients, and methods for manufacturing them.

公开(公告)号：EP1373529A1

公开(公告)日：2004-01-02

申请号：EP02702181.5

申请日：2002-02-25

申请人： NV reMynd

发明人： VAN LEUVEN, Freddy ,  WINDERICKX, Joris

IPC分类号： C12N15/81 ,  C12N15/12 ,  C12N1/21 ,  C12Q1/02

CPC分类号： G01N33/6896 ,  C07K14/4711 ,  C12N15/81 ,  C12Q1/025 ,  G01N2500/00 ,  G01N2800/28

摘要： The present invention relates to cell models of Alzheimer's disease. Transgenic yeast cells are described as models for the tau-opathy in Alzheimer's disease. These cell models comprise recombinant DNA constructs comprising control sequences and a cDNA sequence encoding a human tau-isoform and another similar construct comprising a protein kinase that is capable, directly or indirectly, of modulating the phosphorylation of the microtubule-associated protein tau. The transgenic cells are useful for high-throughput testing for potential therapeutic agents for Alzheimer's disease and other neurodegenerative disorders.

公开(公告)号：EP2035828B1

公开(公告)日：2012-11-28

申请号：EP07725744.2

申请日：2007-06-01

申请人： NV reMYND

发明人： GRIFFIOEN, Gerard ,  COUPET, Kristel, Marie, Edith ,  VAN DAMME, Nele ,  WERA, Stefaan

IPC分类号： G01N33/50 ,  G01N33/68 ,  C12N15/79 ,  C12N15/81

CPC分类号： G01N33/5008 ,  C12N15/81 ,  G01N33/6896

公开(公告)号：EP2188272A2

公开(公告)日：2010-05-26

申请号：EP08786967.3

申请日：2008-08-06

申请人： NV Remynd

发明人： GRIFFIOEN, Gerard ,  ROJAS DE LA PARRA, Veronica ,  LAUWERS, Annick

IPC分类号： C07D277/42 ,  C07D417/06 ,  C07D417/12 ,  C07D417/04 ,  A61K31/496 ,  A61P25/28

CPC分类号： C07D417/06 ,  C07D277/42 ,  C07D417/04 ,  C07D417/12

摘要： This invention provides phenyl- and benzyl-thiazolylpiperazine derivatives, and
N -sulfonyl heterocyclic derivatives including phenyl- and benzyl-thiazolylpiperidine derivatives, and pharmaceutically acceptable salts thereof, for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease.

公开(公告)号：EP1981504A2

公开(公告)日：2008-10-22

申请号：EP07711455.1

申请日：2007-02-07

申请人： NV Remynd

发明人： GRIFFIOEN, Gerard ,  COUPET, Kristel Marie Edith ,  DUHAMEL, Hein Roger ,  WERA, Stefaan ,  GOMME, Ellen ,  VAN DAMME, Nele ,  VAN DER AUWERA, Ingrid ,  LOX, Marleen ,  VAN DOOREN, Tom ,  DECRUY, Tine

IPC分类号： A61K31/496 ,  C07D285/12 ,  C07C257/14 ,  A61P25/00

CPC分类号： C07C257/14 ,  A61K31/496 ,  C07D285/08 ,  C07D285/125 ,  C07D285/135 ,  C07D417/12

摘要： This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease.

公开(公告)号：EP1373529B1

公开(公告)日：2008-04-23

申请号：EP02702181.5

申请日：2002-02-25

申请人： NV reMynd

发明人： VAN LEUVEN, Freddy ,  WINDERICKX, Joris

IPC分类号： C12N15/81 ,  C12N15/12 ,  C12N1/21 ,  C12Q1/02

CPC分类号： G01N33/6896 ,  C07K14/4711 ,  C12N15/81 ,  C12Q1/025 ,  G01N2500/00 ,  G01N2800/28

摘要： The present invention relates to cell models of Alzheimer's disease. Transgenic yeast cells are described as models for the tau-opathy in Alzheimer's disease. These cell models comprise recombinant DNA constructs comprising control sequences and a cDNA sequence encoding a human tau-isoform and another similar construct comprising a protein kinase that is capable, directly or indirectly, of modulating the phosphorylation of the microtubule-associated protein tau. The transgenic cells are useful for high-throughput testing for potential therapeutic agents for Alzheimer's disease and other neurodegenerative disorders.

公开(公告)号：EP2035828A1

公开(公告)日：2009-03-18

申请号：EP07725744.2

申请日：2007-06-01

申请人： NV Remynd

发明人： GRIFFIOEN, Gerard ,  COUPET, Kristel, Marie, Edith ,  VAN DAMME, Nele ,  WERA, Stefaan

IPC分类号： G01N33/50 ,  G01N33/68

CPC分类号： G01N33/5008 ,  C12N15/81 ,  G01N33/6896

摘要： The present invention relates in general to the fields of chemical, pharmaceutical and genetic screening and to diseases associated with protein misfolding. In particular, it discloses engineered cells and a system based thereon that can be used to screen for substances that affect protein misfolding. The engineered cells of the invention comprise one or more reporter genes under transcriptional control of a promoter that is responsive to protein misfolding.