发明公开
- 专利标题： Tricarbonyl complexes of rhenium and technetium comprising amino acids as bidentate ligands and their use as radiotherapeutic chemotoxic agents.
- 专利标题（中）： 的含有氨基酸二齿配体和它们作为化疗毒性放射治疗剂使用铼三羰基复合物。
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申请号： EP10154938.4申请日： 2004-10-20
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公开(公告)号： EP2196222A1公开(公告)日： 2010-06-16
- 发明人: Alberto, Roger , Zobi, Fabio
- 申请人： Universität Zürich
- 申请人地址： Winterthurerstrasse 190 8057 Zürich CH
- 专利权人： Universität Zürich
- 当前专利权人： Universität Zürich
- 当前专利权人地址： Winterthurerstrasse 190 8057 Zürich CH
- 代理机构： Jones, Nicholas Andrew
- 优先权： EP03078086 20031020
- 主分类号： A61K51/04
- IPC分类号： A61K51/04 ; A61K51/08 ; A61P35/00
摘要：
A metal tricarbonyl compound of the general formula
wherein
M is rhenium or technetium or an isotope thereof;
two of X1, X2 and X3 are part of a bidentate ligand and the other one is optionally a monodentate ligand selected from the group consisting of halogens, CO, aromatic heterocycles, thioethers and isocyanides, wherein the aromatic heterocycles are selected from the group consisting of pyridine, pyrimidine, pyrazine, imidazole, pyrazole, triazole, tetrazole, thiazole, and oxazole, wherein the bidentate ligand is an amino acid.
wherein
M is rhenium or technetium or an isotope thereof;
two of X1, X2 and X3 are part of a bidentate ligand and the other one is optionally a monodentate ligand selected from the group consisting of halogens, CO, aromatic heterocycles, thioethers and isocyanides, wherein the aromatic heterocycles are selected from the group consisting of pyridine, pyrimidine, pyrazine, imidazole, pyrazole, triazole, tetrazole, thiazole, and oxazole, wherein the bidentate ligand is an amino acid.
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