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1591 条记录 (耗时 0.032 秒)

    CATIONIC LIPID
    6.
    发明公开
    CATIONIC LIPID 审中-实审

    公开(公告)号：EP4431489A1

    公开(公告)日：2024-09-18

    申请号：EP22892797.6

    申请日：2022-11-09

    申请人： Takeda Pharmaceutical Company Limited

    发明人： MATSUMOTO Satoru ,  OMORI Yoshimasa ,  HOASHI Yasutaka

    IPC分类号： C07C229/12 ,  A61K9/16 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  A61K47/18 ,  A61K48/00

    CPC分类号： A61K9/16 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  A61K47/18 ,  A61K48/00 ,  C07C229/12

    摘要： The present invention provides a technique capable of transferring an active ingredient, particularly, a nucleic acid, to a cell with excellent efficiency and/or to various cells and a cationic lipid for use in this technique, etc. The cationic lipid of the present invention is a compound represented by the following formula (I) or a salt thereof. In the formula (I), W represents -NR1R2 or -N+R11R12R13 (Z-), R1 and R2 each independently represent H or an optionally substituted C1-5 alkyl group, R11, R12 and R13 each independently represent an optionally substituted C1-5 alkyl group, Z- represents an anion, X represents an optionally substituted C2-6 alkylene group, RA and RB each independently represent an optionally substituted C1-17 alkyl group, an optionally substituted C3-17 alkenyl group, an optionally substituted C15-17 alkadienyl group, -R3-C (O)O-R4 or - R3-OC(O)-R4, RC represents -R3-C (O)O-R4 or -R3-OC(O)-R4, R3 represents an optionally substituted C1-16 alkylene group, an optionally substituted C4-16 alkenylene group or an optionally substituted C7-16 alkadienylene group, and R4 represents H, an optionally substituted C1-18 alkyl group, an optionally substituted C3-18 alkenyl group or an optionally substituted C15-18 alkadienyl group.

    METHOD FOR MANUFACTURING GRANULATED BODIES FOR LITHIUM ADSORPTION
    9.
    发明公开
    METHOD FOR MANUFACTURING GRANULATED BODIES FOR LITHIUM ADSORPTION 审中-实审

    公开(公告)号：EP4414065A1

    公开(公告)日：2024-08-14

    申请号：EP22907431.5

    申请日：2022-12-13

    申请人： SUMITOMO METAL MINING CO., LTD.

    发明人： IKEDA, Osamu ,  ASANO, Satoshi ,  TAKANO, Masatoshi ,  MATSUMOTO, Shin-ya ,  KUDO, Yohei ,  HEGURI, Shin-ichi

    IPC分类号： B01J20/30

    CPC分类号： B01J20/30

    摘要： To provide a method for producing granulated body for lithium adsorption that easily maintain their shapes with a high adsorption capability and more robust granulated body. The method for producing the granulated body for lithium adsorption includes a kneading step of kneading a powder of a lithium adsorbent precursor, an organic binder, and a hardening agent for accelerating hardening of the organic binder to obtain a kneaded material, a granulating step of granulating the kneaded material to obtain granulated body, and a baking step of baking the granulated body at 90°C or more and 120°C or less to obtain granulated body for lithium adsorption. This aspect allows obtaining the granulated body for lithium adsorption that easily maintain their shapes with a high adsorption capability and more robust granulated body.

    METHOD FOR MEASURING CELL CONCENTRATION
    10.
    发明公开
    METHOD FOR MEASURING CELL CONCENTRATION 审中-实审

    公开(公告)号：EP4410980A1

    公开(公告)日：2024-08-07

    申请号：EP22876367.8

    申请日：2022-09-28

    申请人： Takeda Pharmaceutical Company Limited

    发明人： YAMAMOTO, Shunsuke ,  NAKAYAMA, Miyu ,  HIRABAYASHI, Hideki

    IPC分类号： C12N15/12 ,  C12Q1/686

    CPC分类号： C12Q1/686 ,  C07K14/435

    摘要： Disclosed is a method for measuring a cell concentration in a sample, the method including the following steps of: (1) measuring the number of copies of a specific gene and a gene of an external standard in a plurality of standard samples each having a known cell concentration by using digital PCR (dPCR); (2) normalizing the measured value of the specific gene measured in the step (1) using the measured value of the external standard and creating a calibration curve on the basis of the normalized value and the known cell concentration; (3) measuring the number of copies of the same specific gene and gene of the external standard in a sample having an unknown cell concentration by using dPCR; and (4) normalizing the measured value of the specific gene measured in the step (3) using the measured value of the external standard and determining a cell concentration using the calibration curve created in the step (2) from the normalized value.