发明公开
EP2198891A1 METHOD FOR PROMOTING THE EXPRESSION OF P53, AND P53 EXPRESSION PROMOTER FOR USE IN THE METHOD
审中-公开
程序对促进P53及P53基因表达启动子表达式使用过程中
- 专利标题： METHOD FOR PROMOTING THE EXPRESSION OF P53, AND P53 EXPRESSION PROMOTER FOR USE IN THE METHOD
- 专利标题（中）： 程序对促进P53及P53基因表达启动子表达式使用过程中
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申请号： EP08829249.5申请日： 2008-09-05
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公开(公告)号： EP2198891A1公开(公告)日： 2010-06-23
- 发明人: KONDO, Shigetada, The University of Tokushima Graduate School , ROKUTAN, Kazuhito The University of Tokushima Graduate School
- 申请人： The University of Tokushima
- 申请人地址： 2-24 Shinkura-cho Tokushima-shi Tokushima 770-8501 JP
- 专利权人： The University of Tokushima
- 当前专利权人： The University of Tokushima
- 当前专利权人地址： 2-24 Shinkura-cho Tokushima-shi Tokushima 770-8501 JP
- 代理机构： Woods, Geoffrey Corlett
- 优先权： JP2007233316 20070907
- 国际公布： WO2009031671 20090312
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K31/337 ; A61K31/7105 ; A61K31/711 ; A61P35/00 ; A61P43/00
摘要：
A method for promoting expression of p53 mRNA and an expression promoting agent for use in the method are provided. The expression of the p53 gene can be promoted by inhibiting the binding between RNA transcribed from exon 1 of the vegf-A gene and mRNA transcribed from the p53 gene. The inhibition of the binding can be achieved by, for example, degrading the RNA transcribed from the exon 1 of the vegf-A gene, inhibiting transcription of RNA from the exon 1 of the vegf-A gene, or binding a nucleic acid that is different from the mRNA transcribed from the p53 gene to the RNA transcribed from the exon 1 of the vegf-A gene.
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