公开(公告)号：EP2907477A1

公开(公告)日：2015-08-19

申请号：EP13842341.3

申请日：2013-09-10

申请人： The University of Tokushima

发明人： SHIGEMOTO, Shuji ,  SATSUMA, Toyoko ,  NOGUCHI, Naoto ,  SUZUKI, Yoshitaka ,  ISHIKAWA, Teruaki ,  OKURA, Kazuo

IPC分类号： A61C19/04 ,  A61C19/045

CPC分类号： A61C19/05 ,  A61B5/1077 ,  A61B5/11 ,  A61B5/1111 ,  A61B5/4547 ,  A61B5/682 ,  A61B5/7246 ,  A61B5/7278 ,  A61B5/7445 ,  A61B2560/0214 ,  A61C9/0006 ,  A61C19/045

摘要： An object of the present invention is to provide a method for quickly acquiring three-dimensional shape data of upper and lower tooth rows. The present invention provides a method for calculating a distance between the upper and lower tooth rows at a high speed, from the three-dimensional shape data of the upper and lower tooth rows thus acquired. Based on technology behind the above methods, the present invention provides a method and an apparatus for performing simulation display of the three-dimensional shapes and an occlusal contact region of the upper and lower tooth rows at a high speed. A jaw movement sensor 30 is fitted to an examinee, and jaw movement data 35 on jaw movement of the examinee is acquired. An impression plate 20 including a rigid flat plate having a top surface and a bottom surface each coated with an impression material is inserted between upper and lower tooth rows of the examinee to which the jaw movement sensor 30 is fitted, and the examinee is guided to perform a temporary occlusion. Impressions left on the impression material 20 and a gauge mark provided on the rigid flat plate are measured by using a three-dimensional shape measuring instrument 25, whereby the three-dimensional shape data of the upper and lower tooth rows and gauge mark data are acquired. Simulation display of movement of the upper and lower tooth rows and occlusal contact regions of the examinee is performed based on the three-dimensional shape data of the upper and lower tooth rows and the gauge mark data, and jaw position data at a time of temporary occlusion and the jaw movement data.

摘要翻译： 本发明的一个目的是提供一种用于快速获取上部和下部齿列的三维形状数据的方法。 本发明提供用于以高的速度计算所述上部和下部齿列之间的距离，从所取得的上部和下部齿列的三维形状数据的方法。 根据上述方法背后的技术，本发明提供用于以高的速度进行三维形状的，并在上部和下部齿列的咬合接触区域模拟显示的方法和设备来。 甲颌运动传感器30在检体被装配到，和颌运动数据对受检者的颌运动35被获取。 印象板20包括具有顶表面和底表面各自在印模材料涂覆有刚性平板被插入到哪个颌运动传感器30装配在受检的上部和下部齿列之间，并能将受检人被引导到 执行临时阻塞。 印象留在印模材料20和设置在所述刚性平板的计量标记是通过使用三维形状测量仪25，由此，上部和下部齿列和标线数据的三维形状数据获取的测量 ， 上部和下部齿列和被检体的咬合接触区域的运动的模拟显示，执行基于所述上部和下部齿列，而标线数据，和颚的位置数据的三维形状数据在临时一个时间 闭塞和钳口移动数据。

公开(公告)号：EP2683404A1

公开(公告)日：2014-01-15

申请号：EP12754536.6

申请日：2012-03-06

申请人： The University of Tokushima

发明人： KAJI, Ryuji

IPC分类号： A61K39/395 ,  A61P21/00 ,  A61P25/00

CPC分类号： A61K39/3955 ,  A61K2039/505 ,  C07K16/241 ,  C07K2317/24 ,  C07K2317/76

摘要： Problem: An object of the present invention is to provide a drug effective for the treatment of ALS, or a method for treating ALS. Solution: The present invention provides an ALS treatment method that improves clinical symptoms of ALS or suppresses the progression of ALS by administering an anti-TNFalfa monoclonal antibody to an ALS patient; an anti-ALS drug containing an anti-TNFalfa monoclonal antibody; an anti-TNFalfa monoclonal antibody for use as an anti-ALS drug; and use of an anti-TNFalfa monoclonal antibody for the treatment of ALS and for the manufacture of a medicament.

摘要翻译： 问题：本发明的目的是提供对治疗ALS有效的药物或治疗ALS的方法。 解决方案：本发明提供ALS治疗方法，其通过向ALS患者施用抗TNFα单克隆抗体来改善ALS的临床症状或抑制ALS的进展; 含有抗TNFα单克隆抗体的抗ALS药物; 用作抗ALS药物的抗TNFα单克隆抗体; 和使用抗TNFα单克隆抗体治疗ALS和制造药物。

公开(公告)号：EP2543387A1

公开(公告)日：2013-01-09

申请号：EP11750631.1

申请日：2011-03-01

申请人： The University of Tokushima

发明人： KIDO Hiroshi ,  MIZUNO Dai

IPC分类号： A61K39/00 ,  A61K9/127 ,  A61K39/02 ,  A61K39/12 ,  A61K39/35 ,  A61K39/39 ,  A61K47/32 ,  A61P31/00 ,  A61P31/16

CPC分类号： C07K14/005 ,  A61K9/0043 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K47/32 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55555 ,  A61K2039/55561 ,  C12N2760/16122 ,  C12N2760/16134 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/466

摘要： A mucosal vaccine producing an antigen-specific mucosal IgA and a blood IgG in the levels capable of exerting an effective immune induction and an infection-preventing effect, which comprises:
(a) an AD vehicle consisting of a synthetic peptide and a lipid(s), wherein the synthetic peptide consisting of the amino acid sequence KnLm (wherein n is 4 to 8 and m is 11 to 20);
(b) a carboxyvinyl polymer; and,
(c) an antigenic protein, in an amount incapable of producing a sufficient mucosal IgA and blood IgG for exerting an effective immune induction and an infection-preventing effect when used by itself.
The mucosal vaccine of the invention has an antibody producing ability which is more potent than those of mucosal vaccines of the prior art, and as a result it can exert an excellent effect even with an extremely small amount of an antigen.

摘要翻译： 一种产生抗原特异性粘膜IgA和血液IgG的粘膜疫苗，其能够发挥有效的免疫诱导和预防感染的效果，其包括：（a）由合成肽和脂质组成的AD介质 ），其中由氨基酸序列KnLm（其中n为4至8且m为11至20）组成的合成肽; （b）羧乙烯基聚合物; 和（c）抗原蛋白质，其量不能产生足够的粘膜IgA和血液IgG，用于在其自身使用时发挥有效的免疫诱导和防感染效果。 本发明的粘膜疫苗具有比现有技术的粘膜疫苗更强的抗体产生能力，因此即使极少量的抗原也能发挥优异的效果。

公开(公告)号：EP2161576B1

公开(公告)日：2012-01-04

申请号：EP09011204.6

申请日：2009-09-01

申请人： FUJIFILM Corporation ,  The University of Tokushima

发明人： Kido, Hiroshi ,  Terashima, Kaoru

IPC分类号： G01N33/53 ,  G01N33/569

CPC分类号： G01N33/6854 ,  G01N33/56983 ,  G01N33/582 ,  G01N2333/11 ,  G01N2800/50

公开(公告)号：EP2390274A1

公开(公告)日：2011-11-30

申请号：EP10733598.6

申请日：2010-01-25

申请人： The University of Tokushima

发明人： TANAKA, Hitoshi

IPC分类号： C08F24/00 ,  C07D317/34 ,  C08F8/02 ,  C08F8/04 ,  C08F8/12 ,  C08F8/30

CPC分类号： C07D317/34 ,  C08F8/02 ,  C08F8/04 ,  C08F8/12 ,  C08F8/30 ,  C08F24/00

摘要： This invention provides a polyfunctional polymer having high stereoregularity, in particular, isotacticity, and provides a production process thereof. The present invention relates to a polymer having, in a molecule, a repeating unit represented by General Formula (2):

wherein R 1 and R 2 are different, and each represents a hydrogen atom, an alkyl group and an aryl group; * represents an asymmetrical carbon,
the polymer containing meso diad (m) and racemo diad (r) at a proportion of 60:40 to 100:0 (m:r).
The invention also relates to chemical modifications and a production process of the polymer.

摘要翻译： 本发明提供具有高立构规整性，特别是全同立构规整度的多官能聚合物，并提供其制备方法。 本发明涉及在分子中具有由通式（2）表示的重复单元的聚合物：其中R 1和R 2不同，各自表示氢原子，烷基和芳基; *表示不对称碳，该聚合物以60:40至100:0（m:r）的比例含有内消旋二（m）和赛摩摩二烯（r）。 本发明还涉及聚合物的化学修饰和生产方法。

公开(公告)号：EP2382996A2

公开(公告)日：2011-11-02

申请号：EP11172230.2

申请日：2006-02-17

申请人： The University of Tokushima ,  NOF Corporation

发明人： KIWADA, Hiroshi ,  ISHIDA, Tatsuhiro ,  ITO, Chika ,  KUBO, Kazuhiro ,  SAKANOUE, Kenji ,  KIKUCHI, Hiroshi

IPC分类号： A61K47/48 ,  C07K5/04 ,  A61K9/127 ,  A61K47/44 ,  C07K7/06 ,  C07K5/08 ,  C07K5/10

CPC分类号： C07K7/06 ,  A61K9/1271 ,  A61K47/60 ,  A61K47/62 ,  C07K5/0806 ,  C07K5/1008

摘要： A polyoxyalkylene chain-containing lipid derivative, which is represented by the following formula (1):

wherein L, Y, W, X 1 , X 2 , X 3 , OA, Z, m1, m2, m3, n1, n2 and n3 are as defined in the specification.

摘要翻译： 由下式（1）表示的含有聚氧化烯链的脂质衍生物：其中L，Y，W，X 1，X 2，X 3，OA，Z，m1，m2，m3，n1，n2和n3 如本说明书中所定义。

公开(公告)号：EP2233437A1

公开(公告)日：2010-09-29

申请号：EP08856953.8

申请日：2008-12-08

申请人： The University of Tokushima

发明人： NAKAMURA, Michihiro

IPC分类号： C01B33/12 ,  A61K9/14 ,  A61K47/02 ,  C08G77/06 ,  C08G77/28 ,  C08G77/38 ,  C12N11/02

CPC分类号： A61K9/1676 ,  C08G77/06 ,  C08G77/20 ,  C08G77/26 ,  C08G77/28 ,  Y10T428/2995

摘要： Provided are nanofunctional silica particles having excellent functionality and quality, and capable of being mass-produced at low costs. According to the present invention, there are provided nanofunctional silica particles including a coating layer containing one or more silica compounds selected from the group consisting of mercaptopropyl trimethoxysilane (MPS), mercaptopropyl triethoxysilane (MPES), mercaptopropyl methyldimethoxysilane (MPDMS), trimethoxy[2-(7-oxabicyclo[4.1.0]-hept-3-yl)ethyl]silane (EpoPS), thiocyanatopropyl triethoxysilane (TCPS), acryloxypropyl trimethoxysilane (ACPS), and aminopropyl trimethoxysilane (APS); and functional particles in the coating layer, and being used in imaging, assay, diagnosis, treatment or the like, medicine or bioresearch.

摘要翻译： 提供具有优异的功能性和质量的纳米官能二氧化硅颗粒，并且能够以低成本批量生产。 根据本发明，提供了纳米官能二氧化硅颗粒，其包括含有一种或多种选自巯基丙基三甲氧基硅烷（MPS），巯基丙基三乙氧基硅烷（MPES），巯基丙基甲基二甲氧基硅烷（MPDMS），三甲氧基[2- （7-氧杂双环[4.1.0]庚基-3-基）乙基]硅烷（EpoPS），硫氰酰丙基三乙氧基硅烷（TCPS），丙烯酰氧基丙基三甲氧基硅烷（ACPS）和氨基丙基三甲氧基硅烷（APS）; 和涂层中的功能性颗粒，用于成像，测定，诊断，治疗等，药物或生物研究。

公开(公告)号：EP2178056A2

公开(公告)日：2010-04-21

申请号：EP09252403.2

申请日：2009-10-13

申请人： NOHMI BOSAI LTD. ,  The University of Tokushima

发明人： Yamagishi, Takatoshi ,  Nakano, Kazuhisa ,  Terada, Kenji

IPC分类号： G08B17/12

CPC分类号： G08B17/125

摘要： Provided is a smoke detecting apparatus capable of detecting occurrence of smoke at high sensitivity while suppressing an effect of disturbance. The smoke detecting apparatus for detecting occurrence of smoke by subjecting an image captured by a monitoring camera to image processing includes: an image memory (10) for storing a plurality of images captured by the monitoring camera in a time series; and a smoke detection area selecting portion (20) for calculating a luminance histogram of the same pixel for each predetermined pixel a plurality of times in a past predetermined period based on the plurality of images stored in the image memory (10), detecting presence or absence of a luminance value that has been newly generated due to occurrence of one of an intrusive object and smoke based on the luminance histogram, and identifying candidate regions to be subjected to the image processing.

公开(公告)号：EP2048754A3

公开(公告)日：2009-09-16

申请号：EP08012762.4

申请日：2008-07-15

申请人： Seoul Opto Device Co., Ltd. ,  The University of Tokushima

发明人： Sakai, Shiro

IPC分类号： H01S5/12 ,  H01L33/00

CPC分类号： H01S5/22 ,  B82Y20/00 ,  H01S5/0202 ,  H01S5/1017 ,  H01S5/105 ,  H01S5/12 ,  H01S5/34333 ,  Y10S977/72

摘要： Disclosed is a laser diode having nano patterns. The laser diode has a substrate (21). A first conductive-type clad layer (35) is disposed over the substrate (21), and a second conductive-type clad layer (41) is disposed over the first conductive-type clad layer (35). An active layer (37) is interposed between the first and second conductive-type clad layers (35,41). Column-shaped nano patterns (42) are periodically arranged at a surface of the second conductive-type clad layer (41). Accordingly, there is provided a laser diode such as a distributed feedback laser diode, which is used in applications where a wavelength parameter is important.

公开(公告)号：EP2048754A2

公开(公告)日：2009-04-15

申请号：EP08012762.4

申请日：2008-07-15

申请人： Seoul Opto Device Co., Ltd. ,  The University of Tokushima

发明人： Sakai, Shiro

IPC分类号： H01S5/12 ,  H01L33/00

CPC分类号： H01S5/22 ,  B82Y20/00 ,  H01S5/0202 ,  H01S5/1017 ,  H01S5/105 ,  H01S5/12 ,  H01S5/34333 ,  Y10S977/72

摘要： Disclosed is a laser diode having nano patterns. The laser diode has a substrate (21). A first conductive-type clad layer (35) is disposed over the substrate (21), and a second conductive-type clad layer (41) is disposed over the first conductive-type clad layer (35). An active layer (37) is interposed between the first and second conductive-type clad layers (35,41). Column-shaped nano patterns (42) are periodically arranged at a surface of the second conductive-type clad layer (41). Accordingly, there is provided a laser diode such as a distributed feedback laser diode, which is used in applications where a wavelength parameter is important.

摘要翻译： 公开了具有纳米图案的激光二极管。 激光二极管具有基板（21）。 第一导电型覆盖层（35）设置在基板（21）的上方，第二导电型覆盖层（41）设置在第一导电型覆盖层（35）的上方。 在第一和第二导电型覆盖层（35,41）之间插入有源层（37）。 在第二导电型覆盖层（41）的表面周期性地布置有柱状纳米图案（42）。 因此，提供了诸如分布式反馈激光二极管的激光二极管，其用于波长参数重要的应用中。